Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata

doi:10.1021/np900309p

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata
	Zhu, Feng 1,2; Di, Ying-Tong1 ; Liu, Ling-Li 1; Zhang, Qiang 1; Fang, Xin 1; Yang, Ting-Quan 1; Hao, Xiao-Jiang1 ; He, Hong-Ping 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2010-02-01
卷号	73 期号:2 页码:233-236
关键词	Glykoside Und Aglykone Dart Poisons Lesch Arrow
ISSN号	0163-3864
DOI	10.1021/np900309p
通讯作者	Hao, XJ, Chinese Acad Sci, Kunming Inst Bot, Stale Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
文献子类	Article
英文摘要	Seven new neoclerodane diterpenoids, scutebatas A-G (1-7), have been isolated front Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their Structures Were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 mu M.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词	ALKALOIDS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000274803600028
资助机构	Ministry of Science and Technology of China [2009CB940900, 2009CB522300]; Natural Science Funding of Yunnan Province [2009CD112]
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4884]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Stale Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Feng,Di, Ying-Tong,Liu, Ling-Li,et al. Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata[J]. JOURNAL OF NATURAL PRODUCTS,2010,73(2):233-236.
APA	Zhu, Feng.,Di, Ying-Tong.,Liu, Ling-Li.,Zhang, Qiang.,Fang, Xin.,...&He, Hong-Ping.(2010).Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata.JOURNAL OF NATURAL PRODUCTS,73(2),233-236.
MLA	Zhu, Feng,et al."Cytotoxic Neoclerodane Diterpenoids from Scutellaria barbata".JOURNAL OF NATURAL PRODUCTS 73.2(2010):233-236.