Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis

doi:10.1021/ol901592f

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis
	Geng, Chang-An1,2 ; Jiang, Zhi-Yong 1; Ma, Yun-Bao 1; Luo, Jie 1; Zhang, Xue-Mei1 ; Wang, Hong-Ling 1,2; Shen, Yong 1,2; Zuo, Ai-Xue 1,2; Zhou, Jun1 ; Chen, Ji-Jun1
刊名	ORGANIC LETTERS
	2009-09-17
卷号	11 期号:18 页码:4120-4123
关键词	Lamivudine Therapy Virus Alkaloids Constituents
ISSN号	1523-7060
DOI	10.1021/ol901592f
文献子类	Article
英文摘要	Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectroscopic methods and further confirmed by X-ray single crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC(50) values of 3.66 and 3.58 mM, respectively.
学科主题	Chemistry, Organic
WOS关键词	LAMIVUDINE THERAPY ; VIRUS ; ALKALOIDS ; CONSTITUENTS
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000269670700024
资助机构	National Natural Science Foundation of China and Yunnan Province [U0832603]; Xibu Zhiguang Joint-Scholarship
公开日期	2012-03-21
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/4264]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Geng, Chang-An,Jiang, Zhi-Yong,Ma, Yun-Bao,et al. Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis[J]. ORGANIC LETTERS,2009,11(18):4120-4123.
APA	Geng, Chang-An.,Jiang, Zhi-Yong.,Ma, Yun-Bao.,Luo, Jie.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2009).Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis.ORGANIC LETTERS,11(18),4120-4123.
MLA	Geng, Chang-An,et al."Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis".ORGANIC LETTERS 11.18(2009):4120-4123.