Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora | |
Xiao, Wei-Lie1; Wang, Rui-Rui2; Zhao, Wei1; Tian, Ren-Rong2; Shang, Shan-Zhai1; Yang, Liu-Meng2; Yang, Jian-Hong1; Pu, Jian-Xin1; Zheng, Yong-Tang2; Sun, Han-Dong1 | |
刊名 | ARCHIVES OF PHARMACAL RESEARCH |
2010-05-01 | |
卷号 | 33期号:5页码:697-701 |
关键词 | Schisandra Rubriflora Lignan Nmr Cd Spectrum Anti-hiv-1 Activity |
ISSN号 | 0253-6269 |
DOI | 10.1007/s12272-010-0508-7 |
文献子类 | Article |
英文摘要 | This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), and seven known lignans (2-8). The structure of 1 was established by extensive 1D and 2D NMR spectroscopy and its absolute stereochemistry was determined by CD spectrum. Compounds 1-5 and 7-8 were evaluated for their anti-HIV-1 activity that showed inhibitory activity on HIV-1(IIIB) induced syncytium formation with EC(50) values in the range of 2.26 similar to 20.4 mu g/mL. Compounds 1 and 7 exerted their obvious protection of HIV-1(IIIB) inducted MT-4 host cells lytic effects with a selectivity index of 15.4 and 24.6, respectively. |
学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
WOS关键词 | SCHIZANDRA-CHINENSIS-BAILL ; DIBENZOCYCLOOCTADIENE LIGNANS ; CONSTITUENTS ; GOMISIN |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000278112400009 |
资助机构 | NSFC [30830115, 20802082] ; Chinese Academy of Sciences [KSCX1-YW-R-24, KSCX2-YW-R-185] ; 973 Program [2009CB522300, 2009CB940900] ; Yong Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47] ; Key Scientific and Technology Projects of China [2009ZX09501-029] |
公开日期 | 2012-03-21 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn:8080/handle/151853/4176] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Xiao, Wei-Lie,Wang, Rui-Rui,Zhao, Wei,et al. Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora[J]. ARCHIVES OF PHARMACAL RESEARCH,2010,33(5):697-701. |
APA | Xiao, Wei-Lie.,Wang, Rui-Rui.,Zhao, Wei.,Tian, Ren-Rong.,Shang, Shan-Zhai.,...&Sun, Han-Dong.(2010).Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora.ARCHIVES OF PHARMACAL RESEARCH,33(5),697-701. |
MLA | Xiao, Wei-Lie,et al."Anti-HIV-1 Activity of Lignans from the Fruits of Schisandra rubriflora".ARCHIVES OF PHARMACAL RESEARCH 33.5(2010):697-701. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论