Isolation, structural elucidation, and chemical transformation of interconvertible 8,12-hemiketal germacranolide sesquiterpenoids from Salvia castanea Diels f. tomentosa Stib.

doi:10.1016/j.tet.2008.07.074

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Isolation, structural elucidation, and chemical transformation of interconvertible 8,12-hemiketal germacranolide sesquiterpenoids from Salvia castanea Diels f. tomentosa Stib.
	Xu, Gang1,2 ; Peng, Li-Yan 1; Hou, Ai-Jun 3; Yang, Jing4 ; Han, Quan-Bin 2; Xu, Hong-Xi 2; Zhao, Qin-Shi1
刊名	TETRAHEDRON
	2008-09-29
卷号	64 期号:40 页码:9490-9494
关键词	Castanins C-f Salvia Castanea Diels F. Tomentosa Stib. Structure Elucidation Interconvertible Hemiketal Isomers Chemical Transformation
ISSN号	0040-4020
DOI	10.1016/j.tet.2008.07.074
文献子类	Article
英文摘要	From the aerial parts of Salvia castanea Diels f. tomentosa Stib., four new hemiketal germacranolide sesquiterpenoids, castanins C-F (1 -4), were obtained as two pairs of interconvertible forms along with their acetates, 5 and 6. Their structures were elucidated by spectroscopic methods and X-ray analysis of the uninterconvertible isomeric acetates, 5 and 6. The computational study explained that the ratios of 1 and 2, 3 and 4, and their acetates (5 and 6) in the mixtures were 1:1, 1:2, and 1:3, respectively. In addition, the semisynthesis of castanins C (1) and D (2) was conducted by the photooxidation of castanin B (8), the major constituent of this plant. Compounds 5, 6, and 8 were also tested for their inhibitory activity toward MCF-7, HeLa, and HepG2 cell lines. (C) 2008 Elsevier Ltd. All rights reserved.
学科主题	Chemistry ; Organic
WOS关键词	LACTONES ; ENERGY ; PALAEFOLIA ; DENSITY
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000259650400019
资助机构	National Natural Science Foundation of China [20702054]; Natural Science Foundation of Yunnan Province [2006C0044Q]
公开日期	2011-11-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/1723]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Shatin, Hong Kong, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200032, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Chem & Chem Technol, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Xu, Gang,Peng, Li-Yan,Hou, Ai-Jun,et al. Isolation, structural elucidation, and chemical transformation of interconvertible 8,12-hemiketal germacranolide sesquiterpenoids from Salvia castanea Diels f. tomentosa Stib.[J]. TETRAHEDRON,2008,64(40):9490-9494.
APA	Xu, Gang.,Peng, Li-Yan.,Hou, Ai-Jun.,Yang, Jing.,Han, Quan-Bin.,...&Zhao, Qin-Shi.(2008).Isolation, structural elucidation, and chemical transformation of interconvertible 8,12-hemiketal germacranolide sesquiterpenoids from Salvia castanea Diels f. tomentosa Stib..TETRAHEDRON,64(40),9490-9494.
MLA	Xu, Gang,et al."Isolation, structural elucidation, and chemical transformation of interconvertible 8,12-hemiketal germacranolide sesquiterpenoids from Salvia castanea Diels f. tomentosa Stib.".TETRAHEDRON 64.40(2008):9490-9494.