Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162
	He, Fei 1; Bao, Jie 1; Zhang, Xiao-Yong 1; Tu, Zheng-Chao 2; Shi, Yi-Ming3 ; Qi, Shu-Hua 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2013-06-01
卷号	76 期号:6 页码:1182-1186
关键词	Cyanobacterium Lyngbya-majuscula Metabolites Biosynthesis Derivatives Agents
ISSN号	0163-3864
通讯作者	Qi, SH (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, 164 West Xingang, Guangzhou 510301, Guangdong, Peoples R China. ; shuhuaqi@scsio.ac.cn
文献子类	Article
英文摘要	A new cytotoxic and antiviral cyclic tetrapeptide, asperterrestide A(1), a new alkaloid, terremide C (2), and a new aromatic butenolide, aspernolide E (A), together with 10 known compounds were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus SCSGAF0162:. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by the Mosher ester technique, and analysis of the acid hydrolysates using a chiral, phase HPLC column. Compound 1 contains a rare 3-OH-N-CH3-Phe residue and showed cytotoxicity against U937 and MOLT4 human carcinoma cell lines and inhibitory effects on influenza virus strains H1N1 and H3N2.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS关键词	CYANOBACTERIUM LYNGBYA-MAJUSCULA ; METABOLITES ; BIOSYNTHESIS ; DERIVATIVES ; AGENTS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000321320600026
资助机构	National Basic Research Program of China (973 Program) [2010CB833803]; National Natural Science Foundation of China [41206130]; National High Technology Research and Development Program of China (863 Program) [2012AA092104]; National Marine Public Welfare Research Project of China [201305017]; Chinese Academy of Sciences [5060267]
公开日期	2013-10-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16777]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,Key Lab Marine, Guangzhou 510301, Guangdong, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	He, Fei,Bao, Jie,Zhang, Xiao-Yong,et al. Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(6):1182-1186.
APA	He, Fei,Bao, Jie,Zhang, Xiao-Yong,Tu, Zheng-Chao,Shi, Yi-Ming,&Qi, Shu-Hua.(2013).Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162.JOURNAL OF NATURAL PRODUCTS,76(6),1182-1186.
MLA	He, Fei,et al."Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162".JOURNAL OF NATURAL PRODUCTS 76.6(2013):1182-1186.