Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity
	Chen, Wen 1; Yang, Li-Juan 2,3; Li, Yan4 ; Wang, Xue-Quan 1; Wang, Shao-Jie 2,3; Wan, Wei-Chao 1; Zhang, Hong-Bin 1; Yang, Xiao-Dong 1
刊名	LETTERS IN DRUG DESIGN & DISCOVERY
	2013-08-01
卷号	10 期号:7 页码:561-571
关键词	Hybrid Compound Imidazole Synthesis Indeno[5 Cytotoxic Activity 6-b]Furan Structure-activity Relationships
ISSN号	1570-1808
通讯作者	Yang, XD (reprint author), Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Yunnan, Peoples R China. ; xdyang@ynu.edu.cn
文献子类	Article
英文摘要	A series of novel hybrid compounds between tricyclic indeno[5,6-b] furan and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl group were vital for modulating cytotoxic activity. In particular, hybrid compound 26 was found to be the most potent compound against 5 strains human tumor cell lines and more active than cisplatin (DDP), while compound 18 was more selective towards breast carcinoma (MCF-7) and colon carcinoma (SW480) with IC50 value 3.4-fold and 4.3-fold more sensitive to DDP.
学科主题	Chemistry, Medicinal
WOS关键词	BIOLOGICAL EVALUATION ; DERIVATIVES ; ANALOGS ; IODIDES ; INDAN ; TRANS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000320915500002
资助机构	NSFC [30960460, 21062026]; NSFYN [2010GA014, 2012FB113]; NBRPC (973 Program) [2009CB522300]; PRTTST of Yunnan Province [2009C1120]
公开日期	2013-10-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16729]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Minist Educ, Key Lab Med Chem Nat Resource, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China 2.Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China 3.Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Chen, Wen,Yang, Li-Juan,Li, Yan,et al. Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2013,10(7):561-571.
APA	Chen, Wen.,Yang, Li-Juan.,Li, Yan.,Wang, Xue-Quan.,Wang, Shao-Jie.,...&Yang, Xiao-Dong.(2013).Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity.LETTERS IN DRUG DESIGN & DISCOVERY,10(7),561-571.
MLA	Chen, Wen,et al."Novel Tricyclic Indeno[5,6-b] furan-imidazole Hybrid Compounds: Design, Synthesis and Antitumor Activity".LETTERS IN DRUG DESIGN & DISCOVERY 10.7(2013):561-571.