Lycospidine A, a New Type of Lycopodium Alkaloid from Lycopodium complanatum

doi:10.1021/ol400907v

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	Lycospidine A, a New Type of Lycopodium Alkaloid from Lycopodium complanatum
	Cheng, Jin-Tang 1,2; Liu, Fei1,2 ; Li, Xiao-Nian 1; Wu, Xing-De 1; Dong, Liao-Bin 1,2; Peng, Li-Yan 1; Huang, Sheng-Xiong1 ; He, Juan 1; Zhao, Qin-Shi1
刊名	ORGANIC LETTERS
	2013-05-17
卷号	15 期号:10 页码:2438-2441
关键词	Inhibiting Acetylcholinesterase A-c Palhinhaea-cernua Lycoposerramine-z Huperzia-serrata Biosynthesis Casuarinoides Intermediate Pelletierine Japonicum
ISSN号	1523-7060
DOI	10.1021/ol400907v
通讯作者	He, J (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China. ; hejuan@mail.kib.ac.cn ; qinshizhao@mail.kib.ac.cn
文献子类	Article
英文摘要	Lycospidine A (1), the first example of a Lycopodium alkaloid which contains an unprecedented five-membered A ring, was Isolated from Lycopodium complanatum. The unique five-membered A ring in 1 indicates that carbons 2-5 in 1 are presumably derived from proline Instead of the lysine biosynthetically, which suggests that 1 represent a new class of Lycopodium alkaloid. In addition, the unique structural feature and biosynthetic origin of 1 shed new insight into the structural diversity of Lycopodium alkaloid analogue libraries potentially accessible by engineered biosynthesis.
学科主题	Chemistry, Organic
WOS关键词	INHIBITING ACETYLCHOLINESTERASE ; A-C ; PALHINHAEA-CERNUA ; LYCOPOSERRAMINE-Z ; HUPERZIA-SERRATA ; BIOSYNTHESIS ; CASUARINOIDES ; INTERMEDIATE ; PELLETIERINE ; JAPONICUM
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000319720900029
资助机构	National Natural Science Foundation of China [U0932602, 90813004]; National Basic Research Program of China (973 Program) [2011CB915503, 2009CB522303] ; National Natural Science Foundation of China(U0932602 ; National Basic Research Program of China (973 Program)(2011CB915503 ; 90813004) ; 2009CB522303)
公开日期	2013-07-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16539]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Jin-Tang,Liu, Fei,Li, Xiao-Nian,et al. Lycospidine A, a New Type of Lycopodium Alkaloid from Lycopodium complanatum[J]. ORGANIC LETTERS,2013,15(10):2438-2441.
APA	Cheng, Jin-Tang.,Liu, Fei.,Li, Xiao-Nian.,Wu, Xing-De.,Dong, Liao-Bin.,...&Zhao, Qin-Shi.(2013).Lycospidine A, a New Type of Lycopodium Alkaloid from Lycopodium complanatum.ORGANIC LETTERS,15(10),2438-2441.
MLA	Cheng, Jin-Tang,et al."Lycospidine A, a New Type of Lycopodium Alkaloid from Lycopodium complanatum".ORGANIC LETTERS 15.10(2013):2438-2441.