A new family of cystine knot peptides from the seeds of Momordica cochinchinensis

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	A new family of cystine knot peptides from the seeds of Momordica cochinchinensis
	Chan, Lai Yue 1; He, Wenjun 2; Tan, Ninghua 2; Zeng, Guangzhi 2; Craik, David J.1; Daly, Norelle L.1,3
刊名	PEPTIDES
	2013
卷号	39 页码:29-35
关键词	Cystine Knot Peptides Mco-3 To Mco-6 Momordica Cochinchinensis
ISSN号	0196-9781
通讯作者	Daly, NL (reprint author), Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia. ; nhtan@mail.kib.ac.cn ; norelle.daly@jcu.edu.au
文献子类	Article
英文摘要	Momordica cochinchinensis, a Cucurbitaceae plant commonly found in Southeast Asia, has the unusual property of containing both acyclic and backbone-cyclized trypsin inhibitors with inhibitor cystine knot (ICK) motifs. In the current study we have shown that M. cochinchinensis also contains another family of acyclic ICK peptides. We recently reported two novel peptides from M. cochinchinensis but have now discovered four additional peptides (MCo-3-MCo-6) with related sequences. Together these peptides form a novel family of M. cochinchinensis ICK( peptides (MCo-ICK) that do not have sequence homology with other known peptides and are not potent trypsin inhibitors. Otherwise these new peptides MCo-3 to MCo-6 were evaluated for antimalarial activity against Plasmodium falciparum, and cytotoxic activity against the cancer cell line MDA-MB-231. But these peptides were not active. (C) 2012 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS关键词	INHIBITOR MCOTI-II ; TRYPSIN-INHIBITOR ; CYTOTOXIC CYCLOTIDES ; SQUASH INHIBITORS ; PLANT CYCLOTIDES ; PROTEINS ; MOTIF ; SPECTROSCOPY ; TOXINS
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000315839300006
资助机构	National Natural Science Foundation of China [U1032602, 91013002, 21202174, 30725048]; China/Australia Special Fund for S T (NSFC); China/Australia Special Fund for S T (ARC); National New Drug Innovation Great Project of China [2011ZX09307-002-02]; National Basic Research Program of China [2009CB522300, 2012CB017104]; foundation of Chinese Academy of Sciences [KSCXZ-EW-R-15]; China Scholarship Council; Queensland Smart State Fellowship
公开日期	2013-07-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/16531]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.James Cook Univ, Sch Pharm & Mol Sci, Ctr Biodiscoveiy & Mol Dev Therapeut, Queensland Trop Hlth Alliance, Cairns, Qld 4870, Australia
推荐引用方式 GB/T 7714	Chan, Lai Yue,He, Wenjun,Tan, Ninghua,et al. A new family of cystine knot peptides from the seeds of Momordica cochinchinensis[J]. PEPTIDES,2013,39:29-35.
APA	Chan, Lai Yue,He, Wenjun,Tan, Ninghua,Zeng, Guangzhi,Craik, David J.,&Daly, Norelle L..(2013).A new family of cystine knot peptides from the seeds of Momordica cochinchinensis.PEPTIDES,39,29-35.
MLA	Chan, Lai Yue,et al."A new family of cystine knot peptides from the seeds of Momordica cochinchinensis".PEPTIDES 39(2013):29-35.