Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities

doi:10.3724/SP.J.1009.2012.00464

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities
	Liu Xu 1,2; Xue Yong-Bo 2; Dong Ke 2; Li Xiao-Nian 2; Li Yan2 ; Pu Jian-Xin2 ; Wu Ji-Zhou 1; Sun Han-Dong2
刊名	CHINESE JOURNAL OF NATURAL MEDICINES
	2012-11-01
卷号	10 期号:6 页码:464-470
关键词	Isodon Rubescens Ent-kaurane Diterpenoids Cytotoxicity Jianshirubesins G-i
ISSN号	1672-3651
DOI	10.3724/SP.J.1009.2012.00464
通讯作者	Wu, JZ (reprint author), Huazhong Univ Sci & Technol, Tongji Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.,ywjz@mails.tjmu.edu.cn ; hdsun@mail.kib.ac.cn
文献子类	Article
英文摘要	AIM: To study the chemical constitutions of the aerial parts of Isodon rubescens in Jianshi county, Hubei Province, China. METHOD: Compounds 1-9 were isolated and purified by normal silica gel and C-18 reversed phase silica gel column chromatography, and HPLC. Their structures were elucidated by extensive spectroscopic methods (IR, UV, MS and NMR), and the absolute configuration of 1 was determined by single crystal X-ray diffraction. Compounds 1-9 were evaluated for their in vitro cytotoxicity against human tumor FIL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. RESULT: Eight ent-kaurane diterpenoids and one ent-gibberellanoid were isolated and identified. CONCLUSIONS: Compounds 1-3 (jianshirubesins G-I) were new diterpenoids, of which 2 was a rare 3, 20-epoxy-ent-kaurane with a hemiketal at C-3. Among all of the diterpenoids tested, compounds 4 and 5 exhibited moderate inhibitory activity on the proliferation of certain cancer cells.
学科主题	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS关键词	ERIOCALYX VAR. LAXIFLORA ; TAIHANGENSIS
WOS研究方向	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000311882500010
资助机构	NSFC-Joint Foundation of Yunnan Province [U0832602]; National Natural Science Foundation of China [81172939]; Major State Basic Research Development Program of China [2009CB522300]; Reservation-Talent Project of Yunnan Province [2011CI043]; Major Direction Projection Foundation of CAS Intellectual Innovation Project [2010KIBA05]
公开日期	2013-01-22
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn:8080/handle/151853/15914]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Tongji Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Liu Xu,Xue Yong-Bo,Dong Ke,et al. Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(6):464-470.
APA	Liu Xu.,Xue Yong-Bo.,Dong Ke.,Li Xiao-Nian.,Li Yan.,...&Sun Han-Dong.(2012).Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities.CHINESE JOURNAL OF NATURAL MEDICINES,10(6),464-470.
MLA	Liu Xu,et al."Three new ent-kaurane diterpenoids from Isodon rubescens and their cytotoxicities".CHINESE JOURNAL OF NATURAL MEDICINES 10.6(2012):464-470.