A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

doi:10.1016/j.ajhg.2009.09.012

CORC > 数学与系统科学研究院 > 中国科学院数学与系统科学研究院 > 系统科学研究所

	A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma
	Landi, Maria Teresa 1; Chatterjee, Nilanjan 1; Yu, Kai 1; Goldin, Lynn R.1; Goldstein, Alisa M.1; Rotunno, Melissa 1; Mirabello, Lisa 1; Jacobs, Kevin 1; Wheeler, William 2; Yeager, Meredith 1
刊名	AMERICAN JOURNAL OF HUMAN GENETICS
	2009-11-13
卷号	85 期号:5 页码:679-691
ISSN号	0002-9297
DOI	10.1016/j.ajhg.2009.09.012
英文摘要	Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of king cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study and three cohort studies. Results were combined with summary data from ten additional studies, for a total of 13,300 cases and 19,666 controls of European descent. Four Studies also provided histology data for replication, resulting in 3333 adenocarcinomas (AD), 2589 squamous cell carcinomas (SQ), and 1418 small cell carcinomas (SQ. In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR] = 1.23, 95% confidence interval [CI] = 1.13-1.33, p = 3.02 x 10(-7)), but not with other histologic types (OR = 1.01, p = 0.84 and OR = 1.00, p = 0.93 for SQ and SC, respectively). This finding was confirmed in each replication study and overall meta-analysis (OR = 1.24, 95% CI = 1.17-1.31, p = 3.74 x 10(-14) for AD; OR = 0.99, p = 0.69 and OR = 0.97, p = 0.48 for SQ and SC, respectively). Other previously reported association signals on 15q25 and 6p21 were also refined, but no additional loci reached genome-wide significance. In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma.
WOS研究方向	Genetics & Heredity
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000271916500014
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/9136]
专题	系统科学研究所
通讯作者	Landi, Maria Teresa
作者单位	1.NCI, Div Canc Epidemiol, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA 2.Informat Management Serv Inc, Rockville, MD 20852 USA 3.SRI Int, Ctr Hlth Sci, Mol Genet program, Menlo Pk, CA 94025 USA 4.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing 100190, Peoples R China 5.Osped Maggiore Policlin Mangiagalli & Regina Elen, Fdn Ist Ricevero & Cura Carattere Sci, Epidemiol Unit, I-20122 Milan, Italy 6.Univ Milan, Dept Occupat & Environm Hlth, I-20122 Milan, Italy 7.Amer Canc Soc Epidemiol & Surveillance Res, Atlanta, GA 30301 USA 8.Univ Minnesota, Hubert H Humphrey Canc Ctr, Minneapolis, MN 55455 USA 9.Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki 00280, Finland 10.Johns Hopkins Univ, Sch Med, Inst Med Genet, Ctr Inherited Dis Res, Baltimore, MD 21224 USA
推荐引用方式 GB/T 7714	Landi, Maria Teresa,Chatterjee, Nilanjan,Yu, Kai,et al. A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2009,85(5):679-691.
APA	Landi, Maria Teresa.,Chatterjee, Nilanjan.,Yu, Kai.,Goldin, Lynn R..,Goldstein, Alisa M..,...&Caporaso, Neil E..(2009).A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma.AMERICAN JOURNAL OF HUMAN GENETICS,85(5),679-691.
MLA	Landi, Maria Teresa,et al."A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma".AMERICAN JOURNAL OF HUMAN GENETICS 85.5(2009):679-691.