Identification of functional modules in a PPI network by clique percolation clustering

doi:10.1016/j.compbiolchem.2006.10.001

CORC > 数学与系统科学研究院 > 中国科学院数学与系统科学研究院 > 应用数学研究所

	Identification of functional modules in a PPI network by clique percolation clustering
	Zhang, Shihua; Ning, Xuemei ; Zhang, Xiang-Sun
刊名	COMPUTATIONAL BIOLOGY AND CHEMISTRY
	2006-12-01
卷号	30 期号:6 页码:445-451
关键词	protein-protein interaction (PPI) network network clustering protein complexes functional modules clique percolation clustering
ISSN号	1476-9271
DOI	10.1016/j.compbiolchem.2006.10.001
英文摘要	Large-scale experiments and data integration have provided the opportunity to systematically analyze and comprehensively understand the topology of biological networks and biochemical processes in cells. Modular architecture which encompasses groups of genes/proteins involved in elementary biological functional units is a basic form of the organization of interacting proteins. Here we apply a graph clustering algorithm based on clique percolation clustering to detect overlapping network modules of a protein-protein interaction (PPI) network. Our analysis of the yeast Sacchromyces cerevisiae suggests that most of the detected modules correspond to one or more experimentally functional modules and half of these annotated modules match well with experimentally determined protein complexes. Our method of analysis can of course be applied to protein-protein interaction data for any species and even other biological networks. (c) 2006 Elsevier Ltd. All rights reserved.
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Computer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000243091500007
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/3884]
专题	应用数学研究所
通讯作者	Zhang, Shihua
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shihua,Ning, Xuemei,Zhang, Xiang-Sun. Identification of functional modules in a PPI network by clique percolation clustering[J]. COMPUTATIONAL BIOLOGY AND CHEMISTRY,2006,30(6):445-451.
APA	Zhang, Shihua,Ning, Xuemei,&Zhang, Xiang-Sun.(2006).Identification of functional modules in a PPI network by clique percolation clustering.COMPUTATIONAL BIOLOGY AND CHEMISTRY,30(6),445-451.
MLA	Zhang, Shihua,et al."Identification of functional modules in a PPI network by clique percolation clustering".COMPUTATIONAL BIOLOGY AND CHEMISTRY 30.6(2006):445-451.