Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA

doi:10.1038/srep13186

	Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA
	Chen, Xing 1,2
刊名	SCIENTIFIC REPORTS
	2015-08-17
卷号	5 页码:11
ISSN号	2045-2322
DOI	10.1038/srep13186
英文摘要	Accumulating experimental studies have indicated that lncRNAs play important roles in various critical biological process and their alterations and dysregulations have been associated with many important complex diseases. Developing effective computational models to predict potential disease-lncRNA association could benefit not only the understanding of disease mechanism at lncRNA level, but also the detection of disease biomarkers for disease diagnosis, treatment, prognosis and prevention. However, known experimentally confirmed disease-lncRNA associations are still very limited. In this study, a novel model of HyperGeometric distribution for LncRNA-Disease Association inference (HGLDA) was developed to predict lncRNA-disease associations by integrating miRNA-disease associations and lncRNA-miRNA interactions. Although HGLDA didn't rely on any known disease-lncRNA associations, it still obtained an AUC of 0.7621 in the leave-one-out cross validation. Furthermore, 19 predicted associations for breast cancer, lung cancer, and colorectal cancer were verified by biological experimental studies. Furthermore, the model of LncRNA Functional Similarity Calculation based on the information of MiRNA (LFSCM) was developed to calculate lncRNA functional similarity on a large scale by integrating disease semantic similarity, miRNA-disease associations, and miRNA-lncRNA interactions. It is anticipated that HGLDA and LFSCM could be effective biological tools for biomedical research.
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000359532600002
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/20523]
专题	中国科学院数学与系统科学研究院
通讯作者	Chen, Xing
作者单位	1.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Chen, Xing. Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA[J]. SCIENTIFIC REPORTS,2015,5:11.
APA	Chen, Xing.(2015).Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA.SCIENTIFIC REPORTS,5,11.
MLA	Chen, Xing."Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA".SCIENTIFIC REPORTS 5(2015):11.