Reverse engineering large-scale genetic networks: synthetic versus real data

	Reverse engineering large-scale genetic networks: synthetic versus real data
	Zhang, Luwen 1,2; Xiao, Mei 1,2; Wang, Yong 3; Zhang, Wu 1
刊名	JOURNAL OF GENETICS
	2010-04-01
卷号	89 期号:1 页码:73-80
关键词	gene regulatory network single gene perturbation linear model stepwise simulated network
ISSN号	0022-1333
英文摘要	Development of microarray technology has resulted in an exponential rise in gene expression data. Linear computational methods are of great assistance in identifying molecular interactions, and elucidating the functional properties of gene networks. It overcomes the weaknesses of in vivo experiments including high cost, large noise, and unrepeatable process. In this paper, we propose an easily applied system, Stepwise Network Inference (SWNI), which integrates deterministic linear model with statistical analysis, and has been tested effectively on both simulated experiments and real gene expression data sets. The study illustrates that connections of gene networks can be significantly detected via SWNI with high confidence, when single gene perturbation experiments are performed complying with the algorithm requirements. In particular, our algorithm shows efficiency and outperforms the existing ones presented in this paper when dealing with large-scale sparse networks without any prior knowledge.
资助项目	Shanghai Leading Academic Discipline Project[J50103]
WOS研究方向	Genetics & Heredity
语种	英语
出版者	INDIAN ACAD SCIENCES
WOS记录号	WOS:000277769500009
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/10953]
专题	中国科学院数学与系统科学研究院
通讯作者	Zhang, Wu
作者单位	1.Shanghai Univ, Sch Comp Engn & Sci, Shanghai 200072, Peoples R China 2.Shanghai Univ, Inst Syst Biol, Shanghai 200072, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Luwen,Xiao, Mei,Wang, Yong,et al. Reverse engineering large-scale genetic networks: synthetic versus real data[J]. JOURNAL OF GENETICS,2010,89(1):73-80.
APA	Zhang, Luwen,Xiao, Mei,Wang, Yong,&Zhang, Wu.(2010).Reverse engineering large-scale genetic networks: synthetic versus real data.JOURNAL OF GENETICS,89(1),73-80.
MLA	Zhang, Luwen,et al."Reverse engineering large-scale genetic networks: synthetic versus real data".JOURNAL OF GENETICS 89.1(2010):73-80.