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	利用microCT研究硫化铋纳米棒在小鼠体内的分布
	郭宏博; 胡西学; 何芳菲; 甘雅玲; 王东亮; 郑晓鹏; 王昱青
	2016
期号	6页码:65-68
关键词	Inductively coupled plasma-mass spectrometry Laser ablation Elemental bio-imaging Single cell analysis Mouse brain sections Gold nanoparticles
英文摘要	Trace elements play very important roles in biological organism and are closely related to many diseases. New analytical methods are urgently needed for in situ determination of trace elements in biological tissues or single cells. A method based on laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was developed here for in situ analysis. Line ablation mode was chosen and the output energy of the laser was optimized at a low fluence of less than 1 J cm(-2). Two kinds of elemental image of both a coronal section from mouse brain and single cells exposed to gold nanoparticles were obtained by the developed method. Due to the unique characteristic, such as good spatial resolution, excellent detection limit, and reasonable running cost, LA-ICP-MS will be applied widely and become a useful tool in biomedical research in the future.
语种	中文
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260472]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	郭宏博,胡西学,何芳菲,等. 利用microCT研究硫化铋纳米棒在小鼠体内的分布[J],2016(6):65-68.
APA	郭宏博.,胡西学.,何芳菲.,甘雅玲.,王东亮.,...&王昱青.(2016).利用microCT研究硫化铋纳米棒在小鼠体内的分布.(6),65-68.
MLA	郭宏博,et al."利用microCT研究硫化铋纳米棒在小鼠体内的分布"..6(2016):65-68.

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