Hesperetin Liposomes for Cancer Therapy

doi:10.2174/1567201812666151027142412

	Hesperetin Liposomes for Cancer Therapy
	Wolfram, J; Scott, B; Boom, K; Shen, JL; Borsoi, C; Suri, K; Grande, R; Fresta, M; Celia, C; Zhao, YL
刊名	CURRENT DRUG DELIVERY
	2016
卷号	13 期号:5 页码:711-719
关键词	Breast cancer Drug delivery Flavanone Lung cancer MDR-1 Natural products
DOI	10.2174/1567201812666151027142412
英文摘要	Hesperetin is a compound from citrus fruit that has previously been found to exert anticancer activity through a variety of mechanisms. However, the application of hesperetin to cancer therapy has been hampered by its hydrophobicity, necessitating the use of toxic solubilizing agents. Here, we have developed the first liposome-based delivery system for hesperetin. Liposomes were fabricated using the thin-layer evaporation technique and physical and pharmacological parameters were measured. The liposomes remained stable for prolonged periods of time in serum and under storage conditions, and displayed anticancer efficacy in both H441 lung cancer cells and MDA-MB-231 breast cancer cells. Furthermore, the anticancer activity was not impaired in cells expressing the multidrug resistance protein 1 (MDR-1). In conclusion, the encapsulation of hesperetin in liposomes does not interfere with therapeutic efficacy and provides a biocompatible alternative to toxic solubilizing agents, thereby enabling future clinical use of this compound for cancer therapy.
语种	英语
WOS记录号	WOS:000384800000008
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/260404]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wolfram, J,Scott, B,Boom, K,et al. Hesperetin Liposomes for Cancer Therapy[J]. CURRENT DRUG DELIVERY,2016,13(5):711-719.
APA	Wolfram, J.,Scott, B.,Boom, K.,Shen, JL.,Borsoi, C.,...&赵宇亮.(2016).Hesperetin Liposomes for Cancer Therapy.CURRENT DRUG DELIVERY,13(5),711-719.
MLA	Wolfram, J,et al."Hesperetin Liposomes for Cancer Therapy".CURRENT DRUG DELIVERY 13.5(2016):711-719.