Detecting the Micro/nano Physical Properties of Single Lymphoma Cells with Atomic Force Microscopy

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	Detecting the Micro/nano Physical Properties of Single Lymphoma Cells with Atomic Force Microscopy
	Liu LQ(刘连庆); Wang B(王博); Li M(李密); Wei FN(魏发南); Liu B(刘斌)
	2017
会议名称	2017 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)
会议日期	Augest 7-11, 2017
会议地点	Shanghai, CHINA
关键词	Atomic force microscopy Lymphoma Image Elasticity Force curve
页码	250-253
通讯作者	Liu B(刘斌)
中文摘要	Non-Hodgkin's lymphoma (NHL) is the most common adult hematological cancer. With the advent of combination therapy of chemotherapy and the monoclonal anti-CD20 antibody Rituximab, the substantial advancement in the treatment of B-cell malignancies has been achieved. In the clinical treatment of NHL, however, there are still many patients who are not sensitive to the therapy of rituximab. Hence investigating the interactions between rituximab and lymphoma cells is crucial for us to understand the actions of rituximab and design drugs with better efficacies. Traditional biochemical methods for cell detection require the various pretreatments of the cell, destroying the structures of cells. This paper uses atomic force microscopy (AFM) to label-free characterize the micro/nano physical properties of single lymphoma cells, including cell morphology, cell elasticity, and molecular interactions on the cell surface. The study improved our understanding of the rituximab actions.
收录类别	EI ; CPCI（ISTP）
产权排序	1
会议主办者	Natl Nat Sci Fdn China, Minist Sci & Technol Peoples Republic of China, Minist Educ Peoples Republic of China, European Commiss, Res Execut Agcy, Jilin Provincial Sci & Technol Dept, IFToMM, Int Soc Nanomfg
会议录	2017 IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (3M-NANO)
会议录出版者	IEEE
会议录出版地	NEW YORK
语种	英语
ISSN号	2373-5422
ISBN号	978-1-5386-1081-7
WOS记录号	WOS:000426927300053
内容类型	会议论文
源URL	[http://ir.sia.cn/handle/173321/21654]
专题	沈阳自动化研究所_机器人学研究室
作者单位	1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences 2.School of Mechanical Engineering and Automation, Fuzhou University
推荐引用方式 GB/T 7714	Liu LQ,Wang B,Li M,et al. Detecting the Micro/nano Physical Properties of Single Lymphoma Cells with Atomic Force Microscopy[C]. 见:2017 7th International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO). Shanghai, CHINA. Augest 7-11, 2017.