Cortical thickness development of human primary visual cortex related to the age of blindness onset

doi:10.1007/s11682-016-9576-8

	Cortical thickness development of human primary visual cortex related to the age of blindness onset
	Li, Qiaojun1,2 ; Song, Ming1,2 ; Xu, Jiayuan 3; Qin, Wen 3; Yu, Chunshui 3; Jiang, Tianzi1,2,4,5 ; Jiang Tianzi
刊名	BRAIN IMAGING AND BEHAVIOR
	2017-08-01
卷号	11 期号:4 页码:1029-1036
关键词	Primary Visual Cortex Cortical Thickness Blindness Age Of Blindness Onset Adolescence
DOI	10.1007/s11682-016-9576-8
文献子类	Article
英文摘要	Blindness primarily induces structural alteration in the primary visual cortex (V1). Some studies have found that the early blind subjects had a thicker V1 compared to sighted controls, whereas late blind subjects showed no significant differences in the V1. This implies that the age of blindness onset may exert significant effects on the development of cortical thickness of the V1. However, no previous research used a trajectory of the age of blindness onset-related changes to investigate these effects. Here we explored this issue by mapping the cortical thickness trajectory of the V1 against the age of blindness onset using data from 99 blind individuals whose age of blindness onset ranged from birth to 34 years. We found that the cortical thickness of the V1 could be fitted well with a quadratic curve in both the left (F = 11.59, P = 3 x 10(-5)) and right hemispheres (F = 6.54, P = 2 x 10(-3)). Specifically, the cortical thickness of the V1 thinned rapidly during childhood and adolescence and did not change significantly thereafter. This trend was not observed in the primary auditory cortex (A1), primary motor cortex (M1), or primary somatosensory cortex (S1). These results provide evidence that an onset of blindness before adulthood significantly affects the cortical thickness of the V1 and suggest a critical period for cortical development of the human V1.
WOS关键词	HUMAN PREFRONTAL CORTEX ; ACTIVATION ; PERFORMANCE ; PLASTICITY ; AWARENESS ; SURFACE ; PERIOD
WOS研究方向	Neurosciences & Neurology
语种	英语
WOS记录号	WOS:000407840500011
资助机构	National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; National Natural Science Foundation of China(91132301 ; 91432302 ; 81471380 ; 81101040)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/12496]
专题	自动化研究所_脑网络组研究中心
通讯作者	Jiang Tianzi
作者单位	1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
推荐引用方式 GB/T 7714	Li, Qiaojun,Song, Ming,Xu, Jiayuan,et al. Cortical thickness development of human primary visual cortex related to the age of blindness onset[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(4):1029-1036.
APA	Li, Qiaojun.,Song, Ming.,Xu, Jiayuan.,Qin, Wen.,Yu, Chunshui.,...&Jiang Tianzi.(2017).Cortical thickness development of human primary visual cortex related to the age of blindness onset.BRAIN IMAGING AND BEHAVIOR,11(4),1029-1036.
MLA	Li, Qiaojun,et al."Cortical thickness development of human primary visual cortex related to the age of blindness onset".BRAIN IMAGING AND BEHAVIOR 11.4(2017):1029-1036.