Weight Multispectral Reconstruction Strategy for Enhanced Reconstruction Accuracy and Stability With Cerenkov Luminescence Tomography

doi:10.1109/TMI.2017.2658661

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Weight Multispectral Reconstruction Strategy for Enhanced Reconstruction Accuracy and Stability With Cerenkov Luminescence Tomography
	Guo, Hongbo 1,2; He, Xiaowei 1; Liu, Muhan 2,3,4; Zhang, Zeyu2,5 ; Hu, Zhenhua2,5,6 ; Tian, Jie2,5,6
刊名	IEEE TRANSACTIONS ON MEDICAL IMAGING
	2017-06-01
卷号	36 期号:6 页码:1337-1346
关键词	Cerenkov Luminescence Tomography Weight Multispectral Reconstruction Inverse Problem
DOI	10.1109/TMI.2017.2658661
文献子类	Article
英文摘要	Cerenkov luminescence tomography (CLT) provides a novel technique for 3-D noninvasive detection of radiopharmaceuticals in living subjects. However, because of the severe scattering of Cerenkov light, the reconstruction accuracy and stability of CLT is still unsatisfied. In this paper, a modified weight multispectral CLT (wmCLT) reconstruction strategy was developed which split the Cerenkov radiation spectrum into several sub-spectral bands and weighted the sub-spectral results to obtain the final result. To better evaluate the property of the wmCLT reconstruction strategy in terms of accuracy, stability and practicability, several numerical simulation experiments and in vivo experiments were conducted and the results obtained were compared with the traditional multispectral CLT (mCLT) and hybrid-spectral CLT (hCLT) reconstruction strategies. The numerical simulation results indicated that wmCLT strategy significantly improved the accuracy of Cerenkov source localization and intensity quantitation and exhibited good stability in suppressing noise in numerical simulation experiments. And the comparison of the results achieved from different in vivo experiments further indicated significant improvement of the wmCLT strategy in terms of the shape recovery of the bladder and the spatial resolution of imaging xenograft tumors. Overall the strategy reported here will facilitate the development of nuclear and optical molecular tomography in theoretical study.
WOS关键词	CONJUGATE-GRADIENT METHOD ; BIOLUMINESCENCE TOMOGRAPHY ; SPARSE RECONSTRUCTION ; CANCER ; PET
WOS研究方向	Computer Science ; Engineering ; Imaging Science & Photographic Technology ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
WOS记录号	WOS:000402722500012
资助机构	National Natural Science Foundation of China(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; 61372046 ; 81527805 ; 61231004 ; 61622117 ; 11571012 ; 81671759 ; 61302024)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/15123]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Northwest Univ, Sch Informat Sci & Technol, Xian 710069, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Xidian Univ, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Peoples R China 4.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 5.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 6.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Guo, Hongbo,He, Xiaowei,Liu, Muhan,et al. Weight Multispectral Reconstruction Strategy for Enhanced Reconstruction Accuracy and Stability With Cerenkov Luminescence Tomography[J]. IEEE TRANSACTIONS ON MEDICAL IMAGING,2017,36(6):1337-1346.
APA	Guo, Hongbo,He, Xiaowei,Liu, Muhan,Zhang, Zeyu,Hu, Zhenhua,&Tian, Jie.(2017).Weight Multispectral Reconstruction Strategy for Enhanced Reconstruction Accuracy and Stability With Cerenkov Luminescence Tomography.IEEE TRANSACTIONS ON MEDICAL IMAGING,36(6),1337-1346.
MLA	Guo, Hongbo,et al."Weight Multispectral Reconstruction Strategy for Enhanced Reconstruction Accuracy and Stability With Cerenkov Luminescence Tomography".IEEE TRANSACTIONS ON MEDICAL IMAGING 36.6(2017):1337-1346.