Spectral CT based radiomics signature: A potential biomarker for preoperative prediction of lymph node metastasis in breast cancer

doi:10.1158/1538-7445.SABCS16-P2-05-38

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Spectral CT based radiomics signature: A potential biomarker for preoperative prediction of lymph node metastasis in breast cancer
	Dong, D.1 ; Zhang, X.; Fang, M.; Shen, J.; Tian, J.
刊名	2016 San Antonio Breast Cancer Symposium
	2017-02-01
卷号	77 期号:-页码:-
关键词	Radiomics
DOI	10.1158/1538-7445.SABCS16-P2-05-38
文献子类	Meeting Abstract
英文摘要	Purpose: To investigate the usefulness of radiomics signature based on computed tomographic (CT) spectral imaging, during the late arterial phase (AP) and portal venous phase (PVP), in preoperative predicting the lymph node (LN) metastasis in breast cancer (BC). patients and methods: This retrospective study was institutional review board approved, and written informed consent was obtained from all patients. We examined 60 female patients (LN metastasis positivity was 50%) with CT spectral imaging during the AP and the PVP and data was gathered from 2014 to 2016. Excised lymph nodes were located and labeled during surgery according to location on preoperative CT images and were evaluated histopathologically. For each patient, two 3D Hounsfeld Unit (HU) gradient maps which revealed the HU change of each voxel were built by quadratic fitting the spectral HU curves during the two phases respectively. Then the radiomics features were then extracted from the regions of BC and a suspicious LN judged manually in these maps. The potential association of the four groups of radiomics features with LN status was assessed by using a Mann-Whitney U test. The area under curves (AUC) of the receiver operating characteristic curves (ROC) were compared with data obtained from the conventional CT image. results: The 3D HU gradient map showed a great power of distinguishing among different components and was considered as a more effective tool for revealing the intratumour heterogeneity than the conventional CT image since the slope of spectral HU curves were significantly higher in malignant tumor. More than 500 radiomics features extracted from the regions of LN during the AP and the PVP exhibited significant differences (P <0.05). Moreover, the numbers of this kind of features extracted from the regions of BC were more than 200. The highest AUC of single feature was 0.70, which was higher than those from the conventional CT image. Conclusion: Quantitative radiomics features based on 3D HU gradient maps have the potential to be exploited as an effective biomarker for preoperative prediction of lymph node metastasis in breast cancer.
WOS研究方向	Oncology
语种	英语
WOS记录号	WOS:000397999001003
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/14429]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 2.Sun Yat Sen Univ, Sun Yet Sun Mem Hosp, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Dong, D.,Zhang, X.,Fang, M.,et al. Spectral CT based radiomics signature: A potential biomarker for preoperative prediction of lymph node metastasis in breast cancer[J]. 2016 San Antonio Breast Cancer Symposium,2017,77(-):-.
APA	Dong, D.,Zhang, X.,Fang, M.,Shen, J.,&Tian, J..(2017).Spectral CT based radiomics signature: A potential biomarker for preoperative prediction of lymph node metastasis in breast cancer.2016 San Antonio Breast Cancer Symposium,77(-),-.
MLA	Dong, D.,et al."Spectral CT based radiomics signature: A potential biomarker for preoperative prediction of lymph node metastasis in breast cancer".2016 San Antonio Breast Cancer Symposium 77.-(2017):-.