Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles

doi:10.1039/c6nr03809c

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles
	Peng, Dong 1,2,3; Du, Yang3,4 ; Shi, Yiwen 5; Mao, Duo 6; Jia, Xiaohua3,4 ; Li, Hui 3; Zhu, Yukun 3; Wang, Kun3,4 ; Tian, Jie1,2,3,4
刊名	NANOSCALE
	2016
卷号	8 期号:30 页码:14480-14488
DOI	10.1039/c6nr03809c
文献子类	Article
英文摘要	Photoacoustic imaging and fluorescence molecular imaging are emerging as important research tools for biomedical studies. Photoacoustic imaging offers both strong optical absorption contrast and high ultrasonic resolution, and fluorescence molecular imaging provides excellent superficial resolution, high sensitivity, high throughput, and the ability for real-time imaging. Therefore, combining the imaging information of both modalities can provide comprehensive in vivo physiological and pathological information. However, currently there are limited probes available that can realize both fluorescence and photoacoustic imaging, and advanced biomedical applications for applying this dual-modality imaging approach remain underexplored. In this study, we developed a dual-modality photoacoustic-fluorescence imaging nanoprobe, ICG-loaded Au@SiO2, which was uniquely designed, consisting of gold nanorod cores and indocyanine green with silica shell spacer layers to overcome fluorophore quenching. This nanoprobe was examined by both PAI and FMI for in vivo imaging on tumor and ischemia mouse models. Our results demonstrated that the nanoparticles can specifically accumulate at the tumor and ischemic areas and be detected by both imaging modalities. Moreover, this dual-modality imaging strategy exhibited superior advantages for a precise diagnosis in different scenarios. The new nanoprobe with the dual-modality imaging approach holds great potential for diagnosis and stage classification of tumor and ischemia related diseases.
WOS关键词	MULTISPECTRAL OPTOACOUSTIC TOMOGRAPHY ; GOLD NANORODS ; COMPUTED-TOMOGRAPHY ; INDOCYANINE GREEN ; LIMB ISCHEMIA ; STRATEGIES ; SILICA ; CANCER ; PROBES ; LIGHT
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
WOS记录号	WOS:000381417800018
资助机构	National Basic Research Program of China (973 Program)(2015CB755500 ; National Natural Science Foundation of China(81227901 ; Key Research Program of the Chinese Academy of Sciences(KGZD-EW-T03) ; Scientific Research and Equipment Development Project of the Chinese Academy of Sciences(YZ201359) ; 2014CB748600) ; 61231004 ; 81527805 ; 61401462)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/12627]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 5.Shanghai Jiao Tong Univ, Dept Biomed Engn, Shanghai 200240, Peoples R China 6.Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117576, Singapore
推荐引用方式 GB/T 7714	Peng, Dong,Du, Yang,Shi, Yiwen,et al. Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles[J]. NANOSCALE,2016,8(30):14480-14488.
APA	Peng, Dong.,Du, Yang.,Shi, Yiwen.,Mao, Duo.,Jia, Xiaohua.,...&Tian, Jie.(2016).Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles.NANOSCALE,8(30),14480-14488.
MLA	Peng, Dong,et al."Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles".NANOSCALE 8.30(2016):14480-14488.