A multivariate pattern analysis study of the HIV-related white matter anatomical structural connections alterations

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	A multivariate pattern analysis study of the HIV-related white matter anatomical structural connections alterations
	Tang Zhenchao; Liu ZY(刘振宇); Tian Jie
	2017-02
会议日期	11 - 16 February 2017
会议地点	Orlando, Florida, United States
关键词	Human Immunodeficiency Virus
英文摘要	It’s widely known that HIV infection would cause white matter integrity impairments. Nevertheless, it is still unclear that how the white matter anatomical structural connections are affected by HIV infection. In the current study, we employed a multivariate pattern analysis to explore the HIV-related white matter connections alterations. Forty antiretroviral-therapy-naïve HIV patients and thirty healthy controls were enrolled. Firstly, an Automatic Anatomical Label (AAL) atlas based white matter structural network, a 90 × 90 FA-weighted matrix, was constructed for each subject. Then, the white matter connections deprived from the structural network were entered into a lasso-logistic regression model to perform HIV-control group classification. Using leave one out cross validation, a classification accuracy (ACC) of 90% (P=0.002) and areas under the receiver operating characteristic curve (AUC) of 0.96 was obtained in the classification model. This result indicated that the white matter anatomical structural connections contributed greatly to HIV-control group classification, providing solid evidence that the white matter connections were affected by HIV infection. Specially, 11 white matter structural connections were selected in the classification model, mainly crossing the regions of frontal lobe, Cingulum, Hippocampus, and Thalamus, which were repeatedly reported damaged in previous HIV study. This might suggested that the white matter connections adjacent to the HIV-related impaired regions were prone to be damaged.
会议录	SPIE Medical Imaging
内容类型	会议论文
源URL	[http://ir.ia.ac.cn/handle/173211/12110]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian Jie
推荐引用方式 GB/T 7714	Tang Zhenchao,Liu ZY,Tian Jie. A multivariate pattern analysis study of the HIV-related white matter anatomical structural connections alterations[C]. 见:. Orlando, Florida, United States. 11 - 16 February 2017.