Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green

doi:10.1038/srep21013

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green
	Fang, Cheng 1,2; Wang, Kun2,3 ; Zeng, Chaoting 1; Chi, Chongwei2,3 ; Shang, Wenting2 ; Ye, Jinzuo2 ; Mao, Yamin2 ; Fan, Yingfang 1; Yang, Jian 1; Xiang, Nan 1
刊名	SCIENTIFIC REPORTS
	2016-02-11
卷号	6 期号:21013 页码:-
关键词	-
DOI	10.1038/srep21013
文献子类	Article
英文摘要	Tissue necrosis commonly accompanies the development of a wide range of serious diseases. Therefore, highly sensitive detection and precise boundary delineation of necrotic tissue via effective imaging techniques are crucial for clinical treatments; however, no imaging modalities have achieved satisfactory results to date. Although fluorescence molecular imaging (FMI) shows potential in this regard, no effective necrosis-avid fluorescent probe has been developed for clinical applications. Here, we demonstrate that indocyanine green (ICG) can achieve high avidity of necrotic tissue owing to its interaction with lipoprotein (LP) and phospholipids. The mechanism was explored at the cellular and molecular levels through a series of in vitro studies. Detection of necrotic tissue and real-time image-guided surgery were successfully achieved in different organs of different animal models with the help of FMI using in house-designed imaging devices. The results indicated that necrotic tissue with a 0.6 mm diameter could be effectively detected with precise boundary definition. We believe that the new discovery and the associated imaging techniques will improve personalized and precise surgery in the near future.
WOS关键词	IN-VIVO ; ACUTE-PANCREATITIS ; CONTRAST AGENTS ; CANCER-SURGERY ; OVARIAN-CANCER ; BREAST-CANCER ; LASER-LIGHT ; ANGIOGRAPHY ; HYPERICIN ; PROTEIN
WOS研究方向	Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000369924700001
资助机构	National Basic Research Program of China (973 Program)(2011CB707700) ; National Natural Science Foundation of China(81227901 ; Open Projects Program of Key Laboratory of Molecular Imaging(Y3SA011x48) ; Equipment research & development project(YZ201164) ; 61231004 ; U1401254)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/11344]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Fang, Cheng,Wang, Kun,Zeng, Chaoting,et al. Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green[J]. SCIENTIFIC REPORTS,2016,6(21013):-.
APA	Fang, Cheng.,Wang, Kun.,Zeng, Chaoting.,Chi, Chongwei.,Shang, Wenting.,...&Tian, Jie.(2016).Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green.SCIENTIFIC REPORTS,6(21013),-.
MLA	Fang, Cheng,et al."Illuminating necrosis: From mechanistic exploration to preclinical application using fluorescence molecular imaging with indocyanine green".SCIENTIFIC REPORTS 6.21013(2016):-.