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	Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals
	Yuan, Yi2,3; Zhu, Zude4; Shi, Jinfu2; Zou, Zhiling5; Yuan, Fei6; Liu, Yijun7,8; Lee, Tatia M. C.1; Weng, Xuchu2; Tatia M.C. Lee
刊名	BRAIN AND COGNITION
	2009-12-01
卷号	71期号:3页码:223-228
关键词	Heroin Addiction Gray matter VBM
ISSN号	0278-2626
文献子类	Article
英文摘要	Numerous studies have documented cognitive impairments and hypoactivity in the prefrontal and anterior cingulate cortices in drug users. However, the relationships between opiate dependence and brain structure changes in heroin users are largely unknown. In the present study, we measured the density of gray matter (DGM) with voxel-based morphometry in 30 lifetime heroin-dependent individuals who had abstained from drug use for 5 months, and 34 healthy participants. The DGM of the prefrontal, temporal and cingulate cortices significantly decreased in heroin addicts relative to the healthy group. Critically, partial correlation analysis, which controlled for age, education and gender factors as well as nicotine use and heroin abstinence duration, showed that the duration of heroin use negatively correlated with the DGM in heroin-dependent individuals. These results provide compelling evidence for structural abnormality in heroin-dependent individuals and further suggest that duration of heroin use is a critical factor leading to brain damage.; Numerous studies have documented cognitive impairments and hypoactivity in the prefrontal and anterior cingulate cortices in drug users. However, the relationships between opiate dependence and brain structure changes in heroin users are largely unknown. In the present study, we measured the density of gray matter (DGM) with voxel-based morphometry in 30 lifetime heroin-dependent individuals who had abstained from drug use for 5 months, and 34 healthy participants. The DGM of the prefrontal, temporal and cingulate cortices significantly decreased in heroin addicts relative to the healthy group. Critically, partial correlation analysis, which controlled for age, education and gender factors as well as nicotine use and heroin abstinence duration, showed that the duration of heroin use negatively correlated with the DGM in heroin-dependent individuals. These results provide compelling evidence for structural abnormality in heroin-dependent individuals and further suggest that duration of heroin use is a critical factor leading to brain damage. (C) 2009 Elsevier Inc. All rights reserved.
学科主题	变态心理学
语种	英语
WOS记录号	WOS:000271664400006
公开日期	2011-08-22
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/5440]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Tatia M.C. Lee
作者单位	1.Univ Hong Kong, Neuropsychol Lab, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Lab Higher Brain Funct, Inst Psychol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China 4.S China Normal Univ, Dept Psychol, Guangzhou, Guangdong, Peoples R China 5.SW China Normal Univ, Dept Psychol, Chongqing, Peoples R China 6.Wujing Med Coll, Dept Radiol, Tianjin, Peoples R China 7.Univ Florida, Dept Psychiat, Gainesville, FL 32610 USA 8.Univ Florida, McKnight Brain Inst, Gainesville, FL 32610 USA
推荐引用方式 GB/T 7714	Yuan, Yi,Zhu, Zude,Shi, Jinfu,et al. Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals[J]. BRAIN AND COGNITION,2009,71(3):223-228.
APA	Yuan, Yi.,Zhu, Zude.,Shi, Jinfu.,Zou, Zhiling.,Yuan, Fei.,...&Tatia M.C. Lee.(2009).Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals.BRAIN AND COGNITION,71(3),223-228.
MLA	Yuan, Yi,et al."Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals".BRAIN AND COGNITION 71.3(2009):223-228.

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