In vivo characterization of hair and skin derived carbon quantum dots with high quantum yield as long-term bioprobes in zebrafish

doi:10.1038/srep37860

CORC > 重庆绿色智能技术研究院 > 中国科学院重庆绿色智能技术研究院 > 环境与健康研究中心

	In vivo characterization of hair and skin derived carbon quantum dots with high quantum yield as long-term bioprobes in zebrafish
	Zhang, Jing-Hui 1,2; Niu, Aping2 ; Li, Jing 1; Fu, Jian-Wei 1; Xu, Qun 1; Pei, De-Sheng2
刊名	SCIENTIFIC REPORTS
	2016-11-25
卷号	6 页码:12
ISSN号	2045-2322
DOI	10.1038/srep37860
通讯作者	Xu, Q (reprint author), Zhengzhou Univ, Coll Mat Sci & Engn, Zhengzhou 450052, Peoples R China. ; Pei, DS (reprint author), Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China.
英文摘要	Carbon quantum dots (CDs) were widely investigated because of their tunable fluorescence properties and low toxicity. However, so far there have been no reports on in vivo functional studies of hair and skin derived CDs. Here, hair derived CDs (HCDs) and skin derived CDs (SCDs) were produced by using human hair and pig skin as precursors. The quantum yields (QYs) of HCDs and SCDs were quite high, compared to citric acid derived CDs (CCDs). HCDs and SCDs possess optimal photostability, hypotoxicity and biocompatibility in zebrafish, indicating that HCDs and SCDs possess the capacity of being used as fluorescence probes for in vivo biological imaging. The long-time observation for fluorescence alternation of CDs in zebrafish and the quenching assay of CDs by ATP, NADH and Fe3+ ions demonstrated that the decaying process of CDs in vivo might be induced by the synergistic effect of the metabolism process. All results indicated that large batches and high QYs of CDs can be acquired by employing natural and nontoxic hair and skin as precursors. To our knowledge, this is the first time to report SCDs, in vivo comparative studies of HCDs, SCDs and CCDs as bioprobes, and explore their mechanism of photostability in zebrafish.
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资助项目	Key Application and Development Program of Chongqing Science and Technology Commission[cstc2014yykfC20004] ; Application and Development Program of Science and Technology Commission of Beibei District, Chongqing[2015-07] ; Scientific Research Starting Foundation for Returned Overseas Chinese Scholars from Ministry of Education ; National Technology Foundation for Selected Overseas Chinese Scholar of Chongqing Human Resources and Social Security Bureau, China
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000388473200001
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/3094]
专题	环境与健康研究中心
通讯作者	Xu, Qun; Pei, De-Sheng
作者单位	1.Zhengzhou Univ, Coll Mat Sci & Engn, Zhengzhou 450052, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jing-Hui,Niu, Aping,Li, Jing,et al. In vivo characterization of hair and skin derived carbon quantum dots with high quantum yield as long-term bioprobes in zebrafish[J]. SCIENTIFIC REPORTS,2016,6:12.
APA	Zhang, Jing-Hui,Niu, Aping,Li, Jing,Fu, Jian-Wei,Xu, Qun,&Pei, De-Sheng.(2016).In vivo characterization of hair and skin derived carbon quantum dots with high quantum yield as long-term bioprobes in zebrafish.SCIENTIFIC REPORTS,6,12.
MLA	Zhang, Jing-Hui,et al."In vivo characterization of hair and skin derived carbon quantum dots with high quantum yield as long-term bioprobes in zebrafish".SCIENTIFIC REPORTS 6(2016):12.