Distinguishing Different Cancerous Human Cells by Raman Spectroscopy Based on Discriminant Analysis Methods | |
Tang, Mingjie1; Xia, Liangping1,2; Wei, Dongshan1; Yan, Shihan1; Du, Chunlei1; Cui, Hong-Liang1,3 | |
刊名 | APPLIED SCIENCES-BASEL |
2017-09-01 | |
卷号 | 7期号:9页码:9 |
关键词 | Raman Spectra Discriminant Analysis Distinguish Human Cells |
ISSN号 | 2076-3417 |
DOI | 10.3390/app7090900 |
英文摘要 | An approach to distinguish eight kinds of different human cells by Raman spectroscopy was proposed and demonstrated in this paper. Original spectra of suspension cells in the frequency range of 623 similar to 1783 cm(-1) were acquired and pre-processed by baseline calibration, and principal component analysis (PCA) was employed to extract the useful spectral information. To develop a robust discrimination model, a linear discriminant analysis (LDA) and quadratic discriminant analysis (QDA) were attempted comparatively in the work. The results showed that the QDA model is better than the LDA model. The optimal QDA model was generated with 12 principal components. The classification rates are 100% in the calibration and prediction set, respectively. From the experimental results, it is concluded that Raman spectroscopy combined with appropriate discriminant analysis methods has significant potential in human cell detection. |
WOS研究方向 | Chemistry ; Materials Science ; Physics |
语种 | 英语 |
出版者 | MDPI AG |
WOS记录号 | WOS:000414453600036 |
内容类型 | 期刊论文 |
源URL | [http://172.16.51.4:88/handle/2HOD01W0/159] |
专题 | 太赫兹技术研究中心 微纳制造与系统集成研究中心 |
作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multiscale Mfg Technol, Chongqing 400714, Peoples R China 2.Yangtze Normal Univ, Sch Elect Informat Engn, Chongqing 408100, Peoples R China 3.Jilin Univ, Coll Instrumentat Sci & Elect Engn, Changchun 130061, Jilin, Peoples R China |
推荐引用方式 GB/T 7714 | Tang, Mingjie,Xia, Liangping,Wei, Dongshan,et al. Distinguishing Different Cancerous Human Cells by Raman Spectroscopy Based on Discriminant Analysis Methods[J]. APPLIED SCIENCES-BASEL,2017,7(9):9. |
APA | Tang, Mingjie,Xia, Liangping,Wei, Dongshan,Yan, Shihan,Du, Chunlei,&Cui, Hong-Liang.(2017).Distinguishing Different Cancerous Human Cells by Raman Spectroscopy Based on Discriminant Analysis Methods.APPLIED SCIENCES-BASEL,7(9),9. |
MLA | Tang, Mingjie,et al."Distinguishing Different Cancerous Human Cells by Raman Spectroscopy Based on Discriminant Analysis Methods".APPLIED SCIENCES-BASEL 7.9(2017):9. |
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