Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室 > 污染过程与控制实验室

	Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics
	Zhang, Linbao 1,2; Liu, Xiaoli 1,2; You, Liping 1,2; Zhou, Di1,2 ; Yu, Junbao1 ; Zhao, Jianmin1 ; Feng, Jianghua 3; Wu, Huifeng1
刊名	CLEAN-SOIL AIR WATER
	2011-11-01
卷号	39 期号:11 页码:989-995
关键词	Biomarker Cadmium Manila Clam Metabolomics Toxicological Effect
ISSN号	1863-0650
通讯作者	Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China
产权排序	[Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Yu, Junbao; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China; [Feng, Jianghua] Xiamen Univ, Dept Elect Sci, Fujian Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen, Peoples R China
文献子类	Article
英文摘要	Cadmium (Cd) has become an important heavy metal contaminant in the sediment and seawater along the Bohai Sea and been of great ecological risk due to its toxic effects to marine organisms. In this work, the toxicological effects caused by environmentally relevant concentrations (10 and 40 mu g L(-1)) of Cd were studied in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48, and 96 h. Both low (10 mu g L(-1)) and high (40 mu g L(-1)) doses of Cd caused the disturbances in energy metabolism and osmotic regulation and neurotoxicity based on the metabolic biomarkers such as succinate, alanine, branched chain amino acids, betaine, hypotaurine, and glutamate in clam gills after 24 h of exposure. However, the recovery of toxicological effects of Cd after exposure for 96 h was obviously observed in clam to Cd exposures. Overall, these results indicated that NMR-based metabolomics was applicable to elucidate the toxicological effects of heavy metal contaminants in the marine bioindicator.; Cadmium (Cd) has become an important heavy metal contaminant in the sediment and seawater along the Bohai Sea and been of great ecological risk due to its toxic effects to marine organisms. In this work, the toxicological effects caused by environmentally relevant concentrations (10 and 40 mu g L(-1)) of Cd were studied in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48, and 96 h. Both low (10 mu g L(-1)) and high (40 mu g L(-1)) doses of Cd caused the disturbances in energy metabolism and osmotic regulation and neurotoxicity based on the metabolic biomarkers such as succinate, alanine, branched chain amino acids, betaine, hypotaurine, and glutamate in clam gills after 24 h of exposure. However, the recovery of toxicological effects of Cd after exposure for 96 h was obviously observed in clam to Cd exposures. Overall, these results indicated that NMR-based metabolomics was applicable to elucidate the toxicological effects of heavy metal contaminants in the marine bioindicator.
学科主题	Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Water Resources
URL标识	查看原文
WOS关键词	MUSSEL MYTILUS-EDULIS ; GLUCOSE DEGRADATION ; TIDAL FLATS ; EXPOSURE ; BIOCHEMISTRY ; BIOSORPTION ; GALLOPROVINCIALIS ; TRANSFORMATION ; SPECTROSCOPY ; METABONOMICS
WOS研究方向	Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Water Resources
语种	英语
WOS记录号	WOS:000297642400022
资助机构	Chinese Academy of Sciences, NSFC[41106102]; Technology Development Program Projects of Shandong Province[2008GG20005006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA
公开日期	2012-03-06
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/5395]
专题	烟台海岸带研究所_污染过程与控制实验室烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室烟台海岸带研究所_滨海湿地实验室烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Xiamen Univ, Dept Elect Sci, Fujian Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics[J]. CLEAN-SOIL AIR WATER,2011,39(11):989-995.
APA	Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Yu, Junbao.,...&Wu, Huifeng.(2011).Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics.CLEAN-SOIL AIR WATER,39(11),989-995.
MLA	Zhang, Linbao,et al."Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics".CLEAN-SOIL AIR WATER 39.11(2011):989-995.