Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 山东省海岸带环境工程技术研究中心

	Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering
	Lou, Tingting 1,2,5; Wang, Yunqing1,2 ; Li, Jinhua1,2 ; Peng, Hailong 3,4; Xiong, Hua 3; Chen, Lingxin1,2
刊名	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
	2011-07-01
卷号	401 期号:1 页码:333-338
关键词	Melamine Surface-enhanced Raman Scattering Gold Nanoparticle 4-mercaptopyridine
ISSN号	1618-2642
通讯作者	Chen, LX, CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China.lxchen@yic.ac.cn
产权排序	[Lou, Tingting; Wang, Yunqing; Li, Jinhua; Chen, Lingxin] CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China; [Lou, Tingting; Wang, Yunqing; Li, Jinhua; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Peng, Hailong; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China; [Peng, Hailong] Nanchang Univ, Dept Chem & Pharmaceut Engn, Nanchang 330031, Peoples R China; [Lou, Tingting] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
文献子类	Article
英文摘要	A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N = 3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices. .; A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N = 3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices.
学科主题	Biochemical Research Methods ; Chemistry, Analytical
WOS关键词	MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; SILVER ELECTRODE ; INFANT FORMULA ; CYANURIC ACID ; SPECTROSCOPY ; MILK ; NANOCRYSTALS ; MOLECULES ; IDENTIFICATION
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
WOS记录号	WOS:000292156900031
资助机构	National Natural Science Foundation China [20807035, 50728806]; Chinese Academy of Sciences [KZCX2-YW-Q07-04]; Agency for Science, technology and Research (A*Star) of Singapore [R-288-000-066-305, 092 101 0059]
公开日期	2011-07-22
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/4852]
专题	烟台海岸带研究所_山东省海岸带环境工程技术研究中心烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 3.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China 4.Nanchang Univ, Dept Chem & Pharmaceut Engn, Nanchang 330031, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lou, Tingting,Wang, Yunqing,Li, Jinhua,et al. Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2011,401(1):333-338.
APA	Lou, Tingting,Wang, Yunqing,Li, Jinhua,Peng, Hailong,Xiong, Hua,&Chen, Lingxin.(2011).Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,401(1),333-338.
MLA	Lou, Tingting,et al."Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 401.1(2011):333-338.