In Vitro Antitumor Activities of Low Molecular Sea Cucumber Stichopus japonicus Peptides Sequentially Hydrolyzed by Proteases

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	In Vitro Antitumor Activities of Low Molecular Sea Cucumber Stichopus japonicus Peptides Sequentially Hydrolyzed by Proteases
	Zhou, Xiaoqiu ; Wang, Changhai ; Jiang, Aili
	2012
会议日期	DEC 28-29, 2011
会议地点	Kunming, PEOPLES R CHINA
关键词	Stichopus Japonicus Peptides Ultrafiltration Antitumor Activities
页码	1259_1262
通讯作者	Zhou, XQ (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res Sustainable Dev, Yantai 264003, Peoples R China.,xqzhou111@163.com ; chwang2001@sina.com ; jal9035@163.com
英文摘要	The sea cucumber (Stichopus japonicus) was continuously hydrolyzed by pepsin, trypsin to get sea cucumber peptides (SCP), and low molecular peptides (LSCP), MW < 3000 Da, were collected through an ultrafiltration membrane with a molecular weight cut-off of 3000 Da Two main fractions, LSCP-1 and LSCP-2 were obtained by one step gel filtration column chromatography. Furthermore, the antitumor activities, in vitro, of LSCP-1 and LSCP-2 fractions were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. LSCP-2 showed significantly antitumor activity against the SGC-7901 and MCF-7 cell lines, LSCP-1 showed significantly antitumor activity only against SGC-7901 cell line, and two fractions did not show activity against A549 cell line. Overall, this study indicated that LSCP posseses potential to treat gastric cancer and breast cancer.
产权排序	[Zhou, Xiaoqiu] Chinese Acad Sci, Yantai Inst Coastal Zone Res Sustainable Dev, Yantai 264003, Peoples R China
会议录	BIOTECHNOLOGY, CHEMICAL AND MATERIALS ENGINEERING, PTS 1-3_Advanced Materials Research
会议录出版者	TRANS TECH PUBLICATIONS LTD
学科主题	Multidisciplinary ; Biotechnology & Applied Microbiology ; Chemical ; Engineering ; Materials Science
语种	英语
URL标识	查看原文
ISSN号	1022-6680
ISBN号	978-3-03785-307-8
内容类型	会议论文
源URL	[http://ir.yic.ac.cn/handle/133337/6258]
专题	烟台海岸带研究所_中科院烟台海岸带研究所知识产出
推荐引用方式 GB/T 7714	Zhou, Xiaoqiu,Wang, Changhai,Jiang, Aili. In Vitro Antitumor Activities of Low Molecular Sea Cucumber Stichopus japonicus Peptides Sequentially Hydrolyzed by Proteases[C]. 见:. Kunming, PEOPLES R CHINA. DEC 28-29, 2011.