A New Anthracene Derivative from Marine Streptomyces sp W007 Exhibiting Highly and Selectively Cytotoxic Activities

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	A New Anthracene Derivative from Marine Streptomyces sp W007 Exhibiting Highly and Selectively Cytotoxic Activities
	Zhang, Hongyu 1,2; Wang, Hongpeng 3; Cui, Hongli 1; Li, Zonggang 4; Xie, Zeping 1; Pu, Yang 1; Li, Fuchao 5; Qin, Song1
刊名	MARINE DRUGS
	2011-09-01
卷号	9 期号:9 页码:1502-1509
关键词	Streptomyces Anthracene Structure Establishment Cytotoxicity
ISSN号	1660-3397
通讯作者	Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
产权排序	[Zhang, Hongyu; Cui, Hongli; Xie, Zeping; Pu, Yang; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhang, Hongyu] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Wang, Hongpeng] Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany; [Li, Zonggang] China Agr Univ, Yantai Inst China Agr Univ, Yantai 264670, Peoples R China; [Li, Fuchao] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
文献子类	Article
英文摘要	A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[alpha]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H-(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[alpha]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.; A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[alpha]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H-(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[alpha]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.
学科主题	Pharmacology & Pharmacy
URL标识	查看原文
WOS关键词	ANTIBIOTICS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000298927500005
资助机构	CAS, Chinese Academy of Sciences[JQ200914, KSCX2-YW-G-073, KZCX2-YW-216, KZCX2-YW-209]; National Natural Science Foundation of China[31000037]
公开日期	2012-03-06
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/5349]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany 4.China Agr Univ, Yantai Inst China Agr Univ, Yantai 264670, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hongyu,Wang, Hongpeng,Cui, Hongli,et al. A New Anthracene Derivative from Marine Streptomyces sp W007 Exhibiting Highly and Selectively Cytotoxic Activities[J]. MARINE DRUGS,2011,9(9):1502-1509.
APA	Zhang, Hongyu.,Wang, Hongpeng.,Cui, Hongli.,Li, Zonggang.,Xie, Zeping.,...&Qin, Song.(2011).A New Anthracene Derivative from Marine Streptomyces sp W007 Exhibiting Highly and Selectively Cytotoxic Activities.MARINE DRUGS,9(9),1502-1509.
MLA	Zhang, Hongyu,et al."A New Anthracene Derivative from Marine Streptomyces sp W007 Exhibiting Highly and Selectively Cytotoxic Activities".MARINE DRUGS 9.9(2011):1502-1509.