The hydroxyl radical scavenging activity of chitosan, hyaluronan, starch and their O-carboxymethylated derivatives

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	The hydroxyl radical scavenging activity of chitosan, hyaluronan, starch and their O-carboxymethylated derivatives
	Yang, Shaoli; Guo, Zhanyong; Miao, Fengping; Xue, Qinzhao; Qin, Song
刊名	CARBOHYDRATE POLYMERS
	2010-11-11
卷号	82 期号:4 页码:1043-1045
关键词	Antioxidant Activity Carboxymethylated Polysaccharides Polysaccharides
ISSN号	0144-8617
通讯作者	Guo, ZY, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
产权排序	[Yang, Shaoli; Guo, Zhanyong; Miao, Fengping; Xue, Qinzhao; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
文献子类	Article
英文摘要	In order to study the effect of active hydroxyl and amino groups on scavenging activity against hydroxyl radicals of polysaccharides, three kinds of carboxymethylated polysaccharides (carboxymethyl chitosan (O-CM-chitosan), carboxymethyl hyaluronan (CMHA), and carboxymethyl starch (CMS)) were prepared and their antioxidant activities against hydroxyl radicals were assessed, respectively. Results showed that O-CM-chitosan had lower scavenging ability on hydroxyl radicals than chitosan. CMHA and CMS had the same tendency. For the three kinds of polysaccharides, scavenging ability on hydroxyl radicals was found to be in the order of chitosan > HA > starch. The scavenging ability of carboxymethylated polysaccharides had the same order as related to its corresponding polysaccharides at higher concentrations (>= 0.8mg/ml). There were not only hydroxyl groups but also amino or acetamino (CH3CONH-) groups in the molecules of chitosan and HA, but only hydroxyl group for starch. It was suggested that the sequence influence the scavenging activity against hydroxyl radicals might be amino group > acetamide group > hydroxyl group. (C) 2010 Elsevier Ltd. All rights reserved.; In order to study the effect of active hydroxyl and amino groups on scavenging activity against hydroxyl radicals of polysaccharides, three kinds of carboxymethylated polysaccharides (carboxymethyl chitosan (O-CM-chitosan), carboxymethyl hyaluronan (CMHA), and carboxymethyl starch (CMS)) were prepared and their antioxidant activities against hydroxyl radicals were assessed, respectively. Results showed that O-CM-chitosan had lower scavenging ability on hydroxyl radicals than chitosan. CMHA and CMS had the same tendency. For the three kinds of polysaccharides, scavenging ability on hydroxyl radicals was found to be in the order of chitosan > HA > starch. The scavenging ability of carboxymethylated polysaccharides had the same order as related to its corresponding polysaccharides at higher concentrations (>= 0.8mg/ml). There were not only hydroxyl groups but also amino or acetamino (CH(3)CONH-) groups in the molecules of chitosan and HA, but only hydroxyl group for starch. It was suggested that the sequence influence the scavenging activity against hydroxyl radicals might be amino group > acetamide group > hydroxyl group. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
URL标识	查看原文
WOS研究方向	Chemistry ; Polymer Science
语种	英语
WOS记录号	WOS:000283042100003
资助机构	Chinese Academy of Sciences [kzcx2-yw-225]; foundation of Special Prize of President Scholarship for Postgraduate Students of Chinese Academy of Sciences
公开日期	2011-07-14
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/3776]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Yang, Shaoli,Guo, Zhanyong,Miao, Fengping,et al. The hydroxyl radical scavenging activity of chitosan, hyaluronan, starch and their O-carboxymethylated derivatives[J]. CARBOHYDRATE POLYMERS,2010,82(4):1043-1045.
APA	Yang, Shaoli,Guo, Zhanyong,Miao, Fengping,Xue, Qinzhao,&Qin, Song.(2010).The hydroxyl radical scavenging activity of chitosan, hyaluronan, starch and their O-carboxymethylated derivatives.CARBOHYDRATE POLYMERS,82(4),1043-1045.
MLA	Yang, Shaoli,et al."The hydroxyl radical scavenging activity of chitosan, hyaluronan, starch and their O-carboxymethylated derivatives".CARBOHYDRATE POLYMERS 82.4(2010):1043-1045.