Hygrocin C from marine-derived Streptomyces sp SCSGAA 0027 inhibits biofilm formation in Bacillus amyloliquefaciens SCSGAB0082 isolated from South China Sea gorgonian

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Hygrocin C from marine-derived Streptomyces sp SCSGAA 0027 inhibits biofilm formation in Bacillus amyloliquefaciens SCSGAB0082 isolated from South China Sea gorgonian
	Wang, J; Nong, XH; Amin, M; Qi, SH
刊名	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
	2018
卷号	102 期号:3 页码:1417-1427
通讯作者	shuhuaqi@scsio.ac.cn
英文摘要	Several ansamycins have been reported to inhibit bacterial biofilm formation and accelerate the eradication of developed biofilms, but little is known about the effect of hygrocin C, an ansamycin, on bacterial biofilm formation. Here, hygrocin C was isolated from the marine-derived Streptomyces sp. SCSGAA 0027 and reported for the first time to be capable of inhibiting the biofilm formation of Staphylococcus aureus and Bacillus amyloliquefaciens SCSGAB0082 with the production of anti-microbial lipopeptides from South China Sea gorgonian Subergorgia suberosa at concentrations of less than minimum inhibitory concentrations. Moreover, hygrocin C also promoted the eradication of developed biofilms, affected the biofilm architecture, and lowered the extracellular polymeric matrix formation, cell motility, and surface hydrophobicity in B. amyloliquefaciens, which was in accordance with the inhibition of biofilm formation. Furthermore, transcriptome analysis revealed that hygrocin C altered the transcripts of several genes associated with bacterial chemotaxis and flagellar, two-component system and the synthesis of arginine and histidine, which are important for bacterial biofilm formation. In conclusion, hygrocin C could be used as a potential biofilm inhibitor against S. aureus and B. amyloliquefaciens. But further genetic investigations are needed to provide more details for elucidation of the molecular mechanisms responsible for the effects of hygrocin C on B. amyloliquefaciens biofilm formation.
学科主题	Biotechnology & Applied Microbiology
关键词[WOS]	Biofilm ; Hygrocin C ; B. amyloliquefaciens ; Transcriptome analysis
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17013]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Wang, J,Nong, XH,Amin, M,et al. Hygrocin C from marine-derived Streptomyces sp SCSGAA 0027 inhibits biofilm formation in Bacillus amyloliquefaciens SCSGAB0082 isolated from South China Sea gorgonian[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2018,102(3):1417-1427.
APA	Wang, J,Nong, XH,Amin, M,&Qi, SH.(2018).Hygrocin C from marine-derived Streptomyces sp SCSGAA 0027 inhibits biofilm formation in Bacillus amyloliquefaciens SCSGAB0082 isolated from South China Sea gorgonian.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,102(3),1417-1427.
MLA	Wang, J,et al."Hygrocin C from marine-derived Streptomyces sp SCSGAA 0027 inhibits biofilm formation in Bacillus amyloliquefaciens SCSGAB0082 isolated from South China Sea gorgonian".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 102.3(2018):1417-1427.