Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure
	Guo, ZQ; Chen, LZ; Zhang, W; Zhang, L
刊名	ENVIRONMENTAL POLLUTION
	2018
卷号	238 页码:17-25
通讯作者	zhangli@scsio.ac.cn
英文摘要	Fish can acclimate to chronic arsenic (As) exposure, but the mechanisms of acclimation remain unclear to date. Therefore, this study conducted 28-d chronic inorganic As [As(III) and As(V)I exposures in fresh-water medaka (Oryzias mekongensis), examined the As bioaccumulation and biotransformation during exposure, and the As acute toxicity and toxicokinetics after exposure. After chronic As(V) exposure, the 96-h lethal concentration (96-h LC50) of As(V) increased 1.3-fold (from 223 to 286 mu mol/L), indicating that the fish became more tolerant to As(V). The As bioaccumulation in As(V)-exposed fish increased gradually during the initial 21-d exposure period and then decreased at 28 d, indicating that acclimation occurred to regulate the total As levels. Toxicokinetics measurement suggested that As(V) uptake (uptake rate constant, k(u)) was significantly decreased and As(III) elimination (efflux rate constant, k(e1)) was significantly increased, both of which could reduce As bioaccumulation. Furthermore, the organic As species became more predominant (50.1-69.3%) in exposed fish, while the inorganic As species were predominant (53.6-56.4%) in the control fish, suggesting that the capability of As biotransformation increased to acclimate inorganic As during chronic exposure. In summary, this study elucidated the acclimation strategies (reduced bioaccumulation and increased biotransformation) of O. mekongensis to counter the ambient As contamination. (C) 2018 Elsevier Ltd. All rights reserved.
学科主题	Environmental Sciences & Ecology
关键词[WOS]	Arsenic ; Acclimation ; Bioaccumulation ; Biotransformation ; Freshwater fish
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16926]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Guo, ZQ,Chen, LZ,Zhang, W,et al. Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure[J]. ENVIRONMENTAL POLLUTION,2018,238:17-25.
APA	Guo, ZQ,Chen, LZ,Zhang, W,&Zhang, L.(2018).Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure.ENVIRONMENTAL POLLUTION,238,17-25.
MLA	Guo, ZQ,et al."Effects of acclimation on arsenic bioaccumulation and biotransformation in freshwater medaka Oryzias mekongensis after chronic arsenic exposure".ENVIRONMENTAL POLLUTION 238(2018):17-25.