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	EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance
	Zheng, Xiaohu1,2,3,4; Fan, Xiaolei1,2,3,4; Fu, Binqing1,2,3,4; Zheng, Meijuan5; Zhang, Aimei6; Zhong, Kai7; Yan, Jialai8; Sun, Rui1,2,3,4; Tian, Zhigang1,2,3,4; Wei, Haiming1,2,3,4
刊名	CANCER RESEARCH
	2017-01-15
卷号	77期号:2页码:482-493
DOI	10.1158/0008-5472.CAN-16-0842
文献子类	Article
英文摘要	The lack of effective tumor-associated antigens restricts the development of targeted therapies against myeloid leukemia. In this study, we compared gene expression patterns of acute myeloid leukemia (AML) and normal bone marrow samples and found that epithelial cell adhesion molecule (EpCAM) is frequently overexpressed in patients with AML, with EpCAM(+) leukemic cells exhibiting enhanced chemoresistance and oncogenesis. The chemotherapeutic resistance of EpCAM-positive leukemic cells is a consequence of increased WNT5B signaling. Furthermore, we generated EpCAM antibodies that enabled phagocytosis or cytotoxicity of AML cells by macrophage or natural killer cells, respectively. Finally, EpCAM antibody treatment depleted AML in subcutaneous, disseminated, and intramedullary engrafted mice. In summary, EpCAM exhibits promise as a novel target for the treatment of leukemia. (C) 2016 AACR.
WOS关键词	ACUTE MYELOID-LEUKEMIA ; CANCER STEM-CELLS ; TRIFUNCTIONAL ANTIBODY CATUMAXOMAB ; HEPATOCELLULAR-CARCINOMA ; MALIGNANT ASCITES ; NK CELLS ; MONOCLONAL-ANTIBODIES ; PHASE II/III ; LUNG-CANCER ; X ANTI-CD3
WOS研究方向	Oncology
语种	英语
WOS记录号	WOS:000393190600026
资助机构	Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; Natural Science Foundation of China(81330071) ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; China Postdoctoral Science Foundation(2015M580555 ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587) ; 2016T90587)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/32819]
专题	合肥物质科学研究院_中科院强磁场科学中心
作者单位	1.Univ Sci & Technol China, Inst Immunol, Sch Life Sci, Hefei, Peoples R China 2.Univ Sci & Technol China, CAS Key Lab Innate Immun & Chron Dis, Sch Life Sci, Hefei, Peoples R China 3.Univ Sci & Technol China, Med Ctr, Hefei, Peoples R China 4.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Peoples R China 5.Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China 6.Anhui Prov Hosp, Hefei, Peoples R China 7.Chinese Acad Sci, High Field Magnet Lab, Hefei, Peoples R China 8.Anhui Med Coll, Dept Med Technol, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Xiaohu,Fan, Xiaolei,Fu, Binqing,et al. EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance[J]. CANCER RESEARCH,2017,77(2):482-493.
APA	Zheng, Xiaohu.,Fan, Xiaolei.,Fu, Binqing.,Zheng, Meijuan.,Zhang, Aimei.,...&Wei, Haiming.(2017).EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance.CANCER RESEARCH,77(2),482-493.
MLA	Zheng, Xiaohu,et al."EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance".CANCER RESEARCH 77.2(2017):482-493.

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