Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin

doi:10.1016/j.snb.2017.02.137

	Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin
	Ma, Xiao-Tong 2; He, Xi-Wen 2; Li, Wen-You 2,3; Zhang, Yu-Kui 1,2
刊名	SENSORS AND ACTUATORS B-CHEMICAL
	2017-07-01
卷号	246 页码:879-886
关键词	Epitope Imprinting Quartz Crystal Microbalance Protein Detection Human Serum Albumin
DOI	10.1016/j.snb.2017.02.137
英文摘要	Quantitative determination of biomacromolecules has great significance. Quartz crystal microbalance sensors are favored by their sensibility while their selectivity was limited. Molecularly imprinted polymer has great selectivity performance. By combining the advantages of quartz crystal microbalance and molecularly imprinted polymer, this work established an epitope molecularly imprinted polymer based quartz crystal microbalance sensor. Using the epitope of human serum albumin as the template, the epitope molecularly imprinted polymer (EMIP) was successfully synthesized. Then a simple coating method was applied to fabricate the epitope molecularly imprinted polymer based quartz crystal microbalance sensor (EMIP-QCM). The EMIP-QCM sensor had good sensibility and selectivity to the target human serum albumin. The linear range was from 0.050u.,mu gmL(-1) to 0.500 mu gmL(-1) and the detection limit was calculated to be 0.026 mu g mL(-1). In addition, it could be used in real sample analysis and had good accuracy and reproducibility. This method proposed a general and simple way of establishing quartz crystal microbalance sensors for sensitive determination of biomacromolecules. (C) 2017 Elsevier B.V. All rights reserved.
语种	英语
WOS记录号	WOS:000400803700107
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/152296]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China 2.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, State Key Lab Med Chem Biol, Coll Chem,Res Ctr Analyt Sci, Tianjin 300071, Peoples R China 3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
推荐引用方式 GB/T 7714	Ma, Xiao-Tong,He, Xi-Wen,Li, Wen-You,et al. Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin[J]. SENSORS AND ACTUATORS B-CHEMICAL,2017,246:879-886.
APA	Ma, Xiao-Tong,He, Xi-Wen,Li, Wen-You,&Zhang, Yu-Kui.(2017).Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin.SENSORS AND ACTUATORS B-CHEMICAL,246,879-886.
MLA	Ma, Xiao-Tong,et al."Epitope molecularly imprinted polymer coated quartz crystal microbalance sensor for the determination of human serum albumin".SENSORS AND ACTUATORS B-CHEMICAL 246(2017):879-886.