New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics

doi:10.1002/adma.201604670

	New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics
	Qing, Guangyan 2; Lu, Qi 2; Xiong, Yuting 2; Zhang, Lei 2,4; Wang, Hongxi ; Li, Xiuling 1; Liang, Xinmiao 1; Sun, Taolei 2,3
刊名	ADVANCED MATERIALS
	2017-05-24
卷号	29
关键词	Enrichment Interfaces Post-translational Modification Proteomics Smart Polymers
DOI	10.1002/adma.201604670
英文摘要	Protein post-translational modifications (PTMs), which denote covalent additions of various functional groups (e.g., phosphate, glycan, methyl, or ubiquitin) to proteins, significantly increase protein complexity and diversity. PTMs play crucial roles in the regulation of protein functions and numerous cellular processes. However, in a living organism, native PTM proteins are typically present at substoichiometric levels, considerably impeding mass-spectrometry-based analyses and identification. Over the past decade, the demand for in-depth PTM proteomics studies has spawned a variety of selective affinity materials capable of capturing trace amounts of PTM peptides from highly complex biosamples. However, novel design ideas or strategies are urgently required for fulfilling the increasingly complex and accurate requirements of PTM proteomics analysis, which can hardly be met by using conventional enrichment materials. Considering two typical types of protein PTMs, phosphorylation and glycosylation, an overview of polymeric enrichment materials is provided here, with an emphasis on the superiority of smart-polymer-based materials that can function in intelligent modes. Moreover, some smart separation materials are introduced to demonstrate the enticing prospects and the challenges of smart polymers applied in PTM proteomics.
语种	英语
WOS记录号	WOS:000401563200014
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/152293]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Peoples R China 3.Wuhan Univ Technol, Int Sch Mat Sci & Engn, 122 Luoshi Rd, Wuhan 430070, Peoples R China 4.Hubei Univ Technol, Coll Bioengn, Inst Biomed & Pharmaceut Sci, 28 Nanli Rd, Wuhan 430068, Peoples R China
推荐引用方式 GB/T 7714	Qing, Guangyan,Lu, Qi,Xiong, Yuting,et al. New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics[J]. ADVANCED MATERIALS,2017,29.
APA	Qing, Guangyan.,Lu, Qi.,Xiong, Yuting.,Zhang, Lei.,Wang, Hongxi.,...&Sun, Taolei.(2017).New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics.ADVANCED MATERIALS,29.
MLA	Qing, Guangyan,et al."New Opportunities and Challenges of Smart Polymers in Post-Translational Modification Proteomics".ADVANCED MATERIALS 29(2017).