Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B

doi:10.1016/j.bmc.2017.02.054

	Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B
	Pudhom, Khanitha 3; Yue, Zongwei 1,2; Mittraphab, Yanisa 3; Lei, Xiaoguang 1,2; Siridechakorn, Ittipon 1,2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2017-06-01
卷号	25 页码:2878-2882
关键词	Endophytic Fungi Rhytidhysteron Rufulum Spirobisnaphthalene Anti-cancer Activity Fungal Cultivation
DOI	10.1016/j.bmc.2017.02.054
英文摘要	The cultivation of the mangrove-derived fungus Rhytidhysteron rufulum AS21B in acidic condition changed its secondary metabolite profile. Investigation of the culture broth extract led to the isolation and identification of two new spirobisnaphthalenes (1 and 2) together with eleven known compounds (313) from the crude extract of the fungus grown under an acidic condition as well as six known compounds (4, 10, 14-17) were isolated from the crude extract of the fungus grown under a neutral condition. Their structures were elucidated on the basis of extensive spectroscopic data. The isolated compounds were evaluated for their cytotoxicity against two human cancer cell lines, Ramos lymphoma and drug resistant NSCLC H1975. Compounds 2 and 10 displayed the most promising anti-tumor activity against both cancer cell lines. (C) 2017 Elsevier Ltd. All rights reserved.
语种	英语
WOS记录号	WOS:000404693600008
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/152073]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn,S, Beijing 100871, Peoples R China 2.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China 3.Chulalongkorn Univ, Dept Chem, Fac Sci, Bangkok 10330, Thailand
推荐引用方式 GB/T 7714	Pudhom, Khanitha,Yue, Zongwei,Mittraphab, Yanisa,et al. Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2017,25:2878-2882.
APA	Pudhom, Khanitha,Yue, Zongwei,Mittraphab, Yanisa,Lei, Xiaoguang,&Siridechakorn, Ittipon.(2017).Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B.BIOORGANIC & MEDICINAL CHEMISTRY,25,2878-2882.
MLA	Pudhom, Khanitha,et al."Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B".BIOORGANIC & MEDICINAL CHEMISTRY 25(2017):2878-2882.