Dynamic seesaw model for rapid signaling responses in eukaryotic chemotaxis

doi:10.1088/1478-3975/aac45b

	Dynamic seesaw model for rapid signaling responses in eukaryotic chemotaxis
	Feng SL; Zhou LW(周吕文); Lv SQ(吕守芹); Zhang Y(章燕)
刊名	PHYSICAL BIOLOGY
	2018-09-01
卷号	15 期号:5
关键词	Polarization Signaling Cascade Mathematical Model Lattice-boltzmann Method
ISSN号	1478-3967
DOI	10.1088/1478-3975/aac45b
文献子类	Article
英文摘要	Directed movement of eukaryotic cells toward spatiotemporally varied chemotactic stimuli enables rapid intracellular signaling responses. While macroscopic cellular manifestation is shaped by balancing external stimuli strength with finite internal delays, the organizing principles of the underlying molecular mechanisms remain to be clarified. Here, we developed a novel modeling framework based on a simple seesaw mechanism to elucidate how cells repeatedly reverse polarity. As a key feature of the modeling, the bottom module of bidirectional molecular transport is successively controlled by three upstream modules of signal reception, initial signal processing, and Rho GTPase regulation. Our simulations indicated that an isotropic cell is polarized in response to a graded input signal. By applying a reversal gradient to a chemoattractant signal, lamellipod-specific molecules (i.e. PIP3 and PI3K) disappear, first from the cell front, and then they redistribute at the opposite side, whereas functional molecules at the rear of the cell (i.e. PIP2 and PTEN) act oppositely. In particular, the model cell exhibits a seesaw-like spatiotemporal pattern for the establishment of front and rear and interconversion, consistent with those related experimental observations. Increasing the switching frequency of the chemotactic gradient causes the cell to stay in a trapped state, further supporting the proposed dynamics of eukaryotic chemotaxis with the underlying cytoskeletal remodeling.
分类号	Q3
WOS关键词	REACTION-DIFFUSION SYSTEM ; CELL POLARITY ; NEUTROPHIL CHEMOTAXIS ; DICTYOSTELIUM CELLS ; RHO-GTPASES ; LOCAL-EXCITATION ; PTEN ; POLARIZATION ; MIGRATION ; MOTILITY
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
WOS记录号	WOS:000433478400001
资助机构	National Natural Science Foundation of China(31230027 ; National Key Research and Development Program of China(2016YFA0501601) ; Strategic Priority Research Program(XDB22040101) ; Frontier Science Key Project(QYZDJ-SSWJSC018) ; 91539119 ; 11502272)
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/77506]
专题	力学研究所_国家微重力实验室
推荐引用方式 GB/T 7714	Feng SL,Zhou LW,Lv SQ,et al. Dynamic seesaw model for rapid signaling responses in eukaryotic chemotaxis[J]. PHYSICAL BIOLOGY,2018,15(5).
APA	Feng SL,周吕文,吕守芹,&章燕.(2018).Dynamic seesaw model for rapid signaling responses in eukaryotic chemotaxis.PHYSICAL BIOLOGY,15(5).
MLA	Feng SL,et al."Dynamic seesaw model for rapid signaling responses in eukaryotic chemotaxis".PHYSICAL BIOLOGY 15.5(2018).