The selective detection of galactose based on boronic acid functionalized fluorescent carbon dots

	The selective detection of galactose based on boronic acid functionalized fluorescent carbon dots
	Chen, Langxing 1,2; Zhang, Yukui 1,3; Yang, Jingai 1; He, Xiwen 1
刊名	ANALYTICAL METHODS
	2016
卷号	8 期号:47 页码:8345-8351
英文摘要	In this paper, we presented a galactose biosensing system based on boronic acid functionalized carbon dots (APBA-Cdots) as the fluorescent probe. Carbon dots were directly synthesized by chemical oxidation with strong acids, and then they were linked to m-aminophenylboronic acid to form the APBA-Cdot fluorescent probe. Boronic acid groups on APBA-Cdot surfaces could covalently react with cis-diol units in galactose to form five- or six-membered cyclic esters. Compared with the close isomeric cousins of galactose such as fructose and glucose, galactose molecules possess more cis-conformational diol units in both pyranose and furanose forms, and as a result, they could selectively lead to the assembly and fluorescence quenching of APBA-Cdots. The fluorescence intensity linearly decreased with increase of galactose concentration in the range of 0 to 500 mu M, and a detection limit as low as 6.2 mu M was achieved. The proposed sensing system has been successfully used for the assay of galactose in human urine.
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine ; Technology
类目[WOS]	Chemistry, Analytical ; Food Science & Technology ; Spectroscopy
研究领域[WOS]	Chemistry ; Food Science & Technology ; Spectroscopy
关键词[WOS]	GRAPHENE QUANTUM DOTS ; CLASSICAL GALACTOSEMIA ; GLUCOSE ; PHOTOLUMINESCENCE ; NANOPARTICLES ; FABRICATION ; ENRICHMENT ; IMPAIRMENT ; TOLERANCE ; URINE
收录类别	SCI
语种	英语
WOS记录号	WOS:000393100700013
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/151893]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, Coll Chem, Res Ctr Analyt Sci, Tianjin 300071, Peoples R China 2.Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Chen, Langxing,Zhang, Yukui,Yang, Jingai,et al. The selective detection of galactose based on boronic acid functionalized fluorescent carbon dots[J]. ANALYTICAL METHODS,2016,8(47):8345-8351.
APA	Chen, Langxing,Zhang, Yukui,Yang, Jingai,&He, Xiwen.(2016).The selective detection of galactose based on boronic acid functionalized fluorescent carbon dots.ANALYTICAL METHODS,8(47),8345-8351.
MLA	Chen, Langxing,et al."The selective detection of galactose based on boronic acid functionalized fluorescent carbon dots".ANALYTICAL METHODS 8.47(2016):8345-8351.