Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways | |
Tang, Miao1,3,4; Zhang, Xiao Chuan1,3,4; Shi, Yun Wei1,3,4; Wang, Cai Ping1,3,4; Ding, Fei1,3,4; Liang, Xin Miao1,3,4,5; Wang, Zhi Wei1,2,3,4; Chen, Chen1,3,4 | |
刊名 | BRAIN BEHAVIOR AND IMMUNITY |
2017-11-01 | |
卷号 | 66页码:244-256 |
关键词 | C5aR1 TLR4 Schisantherin A Inflammation Apoptosis Neuroprotection |
英文摘要 | Toll-like receptor 4 (TLR4) and C5aR1 (CD88) have been recognized as potential therapeutic targets for the reduction of inflammation and secondary damage and improvement of outcome after ischemia and reperfusion (I/R). The inflammatory responses which induce cell apoptosis and necrosis after I/R brain injury lead to a limited process of neural repair. To further comprehend how these targets function in I/R state, we investigated the pathological changes and TLR4 and C5aR1 signaling pathways in vitro and in vivo models of I/12 brain injury in this study. Meanwhile, we explored the roles of schisantherin A on I/R brain injury, and whether it exerted neuroprotective effects by regulating the TLR4 and C5aR1 signaling pathways or not. The results showed that schisantherin A significantly reduced the neuronal apoptosis induced by oxygen and glucose deprivation and reperfusion (OGD/R) injury in primary culture of rat cortical neurons. Also, schisantherin A alleviated neurological deficits, reduced infarct volume, attenuated oxidation stress, inflammation and apoptosis in ischemic parietal cortex of rats after middle cerebral artery occlusion and reperfusion (MCAO/R) injury. Moreover, the activated TLR4 and C5aR1 signaling pathways were inhibited by schisantherin A treatment. In conclusion, TLR4 and C5aR1 played a vital role during I/R. brain injury in rats, and schisantherin A exhibited neuroprotective effects by TLR4 and C5aR1 signaling pathways. These findings also provided new insights that would aid in elucidating the effect of schisantherin A against cerebral I/12 and support the development of schisantherin A as a potential treatment for ischemic stroke. (C) 2017 Elsevier Inc. All rights reserved. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Immunology ; Neurosciences |
研究领域[WOS] | Immunology ; Neurosciences & Neurology |
关键词[WOS] | FOCAL CEREBRAL-ISCHEMIA ; NF-KAPPA-B ; IN-VIVO ; DIBENZOCYCLOOCTADIENE LIGNANS ; FUNCTIONAL RECOVERY ; BRAIN-INJURY ; ACUTE STROKE ; PROTECTS ; COMPLEMENT ; RECEPTOR |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000414236600025 |
内容类型 | 期刊论文 |
源URL | [http://cas-ir.dicp.ac.cn/handle/321008/149713] |
专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
作者单位 | 1.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China 2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA 3.Nantong Univ, Key Lab Neuroregenerat Jiangsu, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China 4.Nantong Univ, Minist Educ, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China 5.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China |
推荐引用方式 GB/T 7714 | Tang, Miao,Zhang, Xiao Chuan,Shi, Yun Wei,et al. Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways[J]. BRAIN BEHAVIOR AND IMMUNITY,2017,66:244-256. |
APA | Tang, Miao.,Zhang, Xiao Chuan.,Shi, Yun Wei.,Wang, Cai Ping.,Ding, Fei.,...&Chen, Chen.(2017).Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways.BRAIN BEHAVIOR AND IMMUNITY,66,244-256. |
MLA | Tang, Miao,et al."Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways".BRAIN BEHAVIOR AND IMMUNITY 66(2017):244-256. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论