Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways

doi:10.3892/ijo.2015.2863

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	Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways
	Wang, GX; Dai, F; Yu, K; Jia, ZF; Zhang, AL; Huang, Q; Kang, CS; Jiang, H; Pu, PY; Pu, PY (reprint author), Tianjin Med Univ Gen Hosp, Dept Neurosurg, 154 An Shan Rd, Tianjin 300052, Peoples R China.
刊名	INTERNATIONAL JOURNAL OF ONCOLOGY
	2015-04
卷号	46 期号:4 页码:1739-1747
关键词	apoptosis cell growth glioma microRNA resveratrol
ISSN号	1019-6439
DOI	10.3892/ijo.2015.2863
文献子类	Article
英文摘要	Resveratrol (Res), a natural polyphenolic compound, has anticancer activity in a variety of cancers. In the present study, the antitumor effect and underlying molecular mechanism of Res on rat C6 glioma growth was studied. The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S phase and induced apoptosis in vitro. Res also suppressed intracranial C6 tumor growth in vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantltly downregulated the specific miRs, including miR-21, miR-30a-5p and miR-19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-kappa B and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas.
学科主题	Oncology
出版地	ATHENS
资助项目	国家自然科学基金项目
项目编号	Natural Science Foundation of China [81101915]
语种	英语
WOS记录号	WOS:000350616400035
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178495]
专题	学院待认领_期刊论文
通讯作者	Pu, PY (reprint author), Tianjin Med Univ Gen Hosp, Dept Neurosurg, 154 An Shan Rd, Tianjin 300052, Peoples R China.
推荐引用方式 GB/T 7714	Wang, GX,Dai, F,Yu, K,et al. Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2015,46(4):1739-1747.
APA	Wang, GX.,Dai, F.,Yu, K.,Jia, ZF.,Zhang, AL.,...&Pu, PY .(2015).Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways.INTERNATIONAL JOURNAL OF ONCOLOGY,46(4),1739-1747.
MLA	Wang, GX,et al."Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways".INTERNATIONAL JOURNAL OF ONCOLOGY 46.4(2015):1739-1747.