Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci

doi:10.1038/srep41195

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	Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci
	Yao, HB; Wang, CC; Wang, J; Tao, XL; Shang, L; Wen, SQ; Du, QJ; Deng, QY; Xu, BY; Huang, Y
刊名	SCIENTIFIC REPORTS
	2017-01-23
卷号	7
ISSN号	2045-2322
DOI	10.1038/srep41195
文献子类	Article
英文摘要	The origin and diversification of Sino-Tibetan speaking populations have been long-standing hot debates. However, the limited genetic information of Tibetan populations keeps this topic far from clear. In the present study, we genotyped 15 forensic autosomal short tandem repeats (STRs) from 803 unrelated Tibetan individuals from Gansu Province (635 from Gannan and 168 from Tianzhu) in northwest China. We combined these data with published dataset to infer a detailed population affinities and genetic substructure of Sino-Tibetan populations. Our results revealed Tibetan populations in Gannan and Tianzhu are genetically very similar with Tibetans from other regions. The Tibetans in Tianzhu have received more genetic influence from surrounding lowland populations. The genetic structure of Sino-Tibetan populations was strongly correlated with linguistic affiliations. Although the among-population variances are relatively small, the genetic components for Tibetan, Lolo-Burmese, and Han Chinese were quite distinctive, especially for the Deng, Nu, and Derung of Lolo-Burmese. Han Chinese but not Tibetans are suggested to share substantial genetic component with southern natives, such as Tai-Kadai and Hmong-Mien speaking populations, and with other lowland East Asian populations, which implies there might be extensive gene flow between those lowland groups and Han Chinese after Han Chinese were separated from Tibetans. The dataset generated in present study is also valuable for forensic identification and paternity tests in China.
学科主题	Science & Technology - Other Topics
出版地	LONDON
资助项目	国家自然科学基金项目 ; 甘肃省青年科技基金计划 ; 甘肃省自然科学基金计划
项目编号	Natural Science Foundation of Gansu province [1308RJZA190] ; Scientific Research Project for Colleges of Gansu province [2014A-085] ; National Excellent Youth Science Foundation of China [31222030] ; National Natural Science Foundation of China [31671297, 31071098] ; Max Planck Society ; European Research Council (ERC) under the European Union's Horizon research and innovation programme [646612]
语种	英语
WOS记录号	WOS:000392420100001
资助机构	NSFC ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188695]
专题	第二临床医学院_期刊论文
通讯作者	Wang, CC; Yao, HB (reprint author), Gansu Inst Polit Sci & Law, Key Lab Evidence Sci Gansu Prov, Lanzhou 730070, Peoples R China.; Li, H (reprint author), Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, State Key Lab Genet Engn, Shanghai 200433, Peoples R China.; Li, H (reprint author), Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, Key Lab Contemporary Anthropol,Minist Educ, Shanghai 200433, Peoples R China.
推荐引用方式 GB/T 7714	Yao, HB,Wang, CC,Wang, J,et al. Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci[J]. SCIENTIFIC REPORTS,2017,7.
APA	Yao, HB.,Wang, CC.,Wang, J.,Tao, XL.,Shang, L.,...&Li, H .(2017).Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci.SCIENTIFIC REPORTS,7.
MLA	Yao, HB,et al."Genetic structure of Tibetan populations in Gansu revealed by forensic STR loci".SCIENTIFIC REPORTS 7(2017).