Short-term diabetes- and diuresis-induced alterations of the bladder are mostly reversible in rats

doi:10.1111/iju.12695

CORC > 兰州大学 > 兰州大学 > 第二临床医学院 > 期刊论文

	Short-term diabetes- and diuresis-induced alterations of the bladder are mostly reversible in rats
	Xiao, N; Huang, YX; Kavran, M; Elrashidy, RA; Liu, GM; Liu, GM (reprint author), Case Western Reserve Univ, Sch Med, Dept Urol, Urol Inst,Univ Hosp Case Med Ctr, 10900 Euclid Ave, Cleveland, OH 44106 USA.
刊名	INTERNATIONAL JOURNAL OF UROLOGY
	2015-04
卷号	22 期号:4 页码:410-415
关键词	bladder diabetes insulin morphology smooth muscle
ISSN号	0919-8172
DOI	10.1111/iju.12695
文献子类	Article
英文摘要	ObjectivesTo determine whether diabetes mellitus- and diuresis-induced alterations in the bladder can be reversed in rats. MethodsMale Sprague-Dawley rats were randomly distributed into eight groups (n=16 per group): 3weeks and 11weeks age-matched controls, 3weeks and 11weeks after streptozotocin-induced diabetes mellitus, 3weeks after diabetes mellitus induction then treated with insulin for 8weeks, 3weeks and 11weeks after 5% sucrose-induced diuresis, and 3weeks after 5% sucrose-induced diuresis followed by removal of 5% sucrose for 8weeks. Bodyweight, blood glucose and glycated hemoglobin A1c were monitored. At the designated time-points, 24-h urinary habits were examined, and cystometry was carried out in half of the animals. The bladders from the remaining animals were harvested for histological examination, and quantification of smooth muscle, urothelium and collagen components. ResultsInsulin treatment reversed hyperglycemia and polyuria in diabetic animals successfully, which was shown by normalization of blood glucose, glycated hemoglobin A1c and 24-h urinary habits. Subsequently, bodyweight, bladder weight and percentage change of bladder components (smooth muscle, collagen, urothelium) in total bladder cross-sectional area were reversed to almost normal levels, and the bladder dysfunction was mostly reversed by 8weeks of glycemic control, seen in the cystometry study. Similar alterations and reversed effects were seen in diuretic rats without and with 5% sucrose removal, respectively. ConclusionsShort-term (3-week induction) diabetes- and polyuria-induced functional and morphological alterations of the bladder can mostly be reversed in rats.
学科主题	Urology & Nephrology
出版地	HOBOKEN
资助项目	国家留学基金委项目
项目编号	NIDDK Diabetic Complications Consortium [DK076169] ; Postgraduate Study Abroad Scholarship Program from the China Scholarship Council
语种	英语
WOS记录号	WOS:000352228500017
资助机构	CSC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179350]
专题	第二临床医学院_期刊论文
通讯作者	Liu, GM (reprint author), Case Western Reserve Univ, Sch Med, Dept Urol, Urol Inst,Univ Hosp Case Med Ctr, 10900 Euclid Ave, Cleveland, OH 44106 USA.
推荐引用方式 GB/T 7714	Xiao, N,Huang, YX,Kavran, M,et al. Short-term diabetes- and diuresis-induced alterations of the bladder are mostly reversible in rats[J]. INTERNATIONAL JOURNAL OF UROLOGY,2015,22(4):410-415.
APA	Xiao, N,Huang, YX,Kavran, M,Elrashidy, RA,Liu, GM,&Liu, GM .(2015).Short-term diabetes- and diuresis-induced alterations of the bladder are mostly reversible in rats.INTERNATIONAL JOURNAL OF UROLOGY,22(4),410-415.
MLA	Xiao, N,et al."Short-term diabetes- and diuresis-induced alterations of the bladder are mostly reversible in rats".INTERNATIONAL JOURNAL OF UROLOGY 22.4(2015):410-415.