Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway

doi:10.1155/2016/5901098

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	Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway
	Bae, WJ; Ha, US; Choi, JB; Kim, KS; Kim, SJ; Cho, HJ; Hong, SH; Lee, JY; Wang, ZP; Hwang, SY
刊名	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
	2016
ISSN号	1942-0900
DOI	10.1155/2016/5901098
文献子类	Article
英文摘要	Higher testicular temperature results in altered spermatogenesis due to heat-related oxidative stress. We examined the effects of decursin extracted from Angelica gigas Nakai on antioxidant activity in vitro and in a cryptorchidism-induced infertility rat model. TM3 Leydig cell viability was measured based on oxidative stress according to treatment. Either distilled water or AG 400 mg/kg of A. gigas extract was administered orally for 4 weeks after unilateral cryptorchidism was induced. After 1, 2, and 4 weeks, six rats from the control group and six rats from treatment group were sacrificed. Testicular weight, semen quality, antioxidant activities, nuclear factor erythroid 2-related factor 2 (Nrf2) protein, and mRNA expression of Nrf2-regulated genes were analyzed. Treatment with A. gigas extract (1) protected TM3 cells against oxidative stress in a dose-dependent manner, (2) improved the mean weight of the cryptorchid testis, (3) maintained sperm counts, motility, and spermatogenic cell density, (4) decreased levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and increased levels of superoxide dismutase (SOD), (5) significantly increased Nrf2 and heme oxygenase-1 (HO-1), and (6) significantly decreased apoptosis. This study suggests that decursin extracted from A. gigas is a supplemental agent that can reduce oxidative stress by Nrf2-mediated upregulation of HO-1 in rat experimentally induced unilateral cryptorchidism and may improve cryptorchidism-induced infertility.
学科主题	Cell Biology
出版地	NEW YORK
项目编号	Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), - Ministry of Health & Welfare, Republic of Korea [HI15C0099] ; Research Fund of Seoul St. Mary's Hospital, The Catholic University of Korea
语种	英语
WOS记录号	WOS:000371050300001
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179326]
专题	第二临床医学院_期刊论文
通讯作者	Kim, SW (reprint author), Catholic Univ Korea, Coll Med, Catholic Integrat Med Res Inst, Seoul 137701, South Korea.; Kim, SW (reprint author), Catholic Univ Korea, Coll Med, Dept Urol, Banpo Daero 222, Seoul 137701, South Korea.
推荐引用方式 GB/T 7714	Bae, WJ,Ha, US,Choi, JB,et al. Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2016.
APA	Bae, WJ.,Ha, US.,Choi, JB.,Kim, KS.,Kim, SJ.,...&Kim, SW .(2016).Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY.
MLA	Bae, WJ,et al."Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016).