An evidence-based medicine review of lymphadenectomy extent for gastric cancer

doi:10.1016/j.amjsurg.2008.05.001

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	An evidence-based medicine review of lymphadenectomy extent for gastric cancer
	Yang, SH; Zhang, YC; Yang, KH; Li, YP; He, XD; Tian, JH; Lv, TH; Hui, YH; Sharma, N; Zhang, YC (reprint author), Lanzhou Univ, Hosp 2, Dept Gen Surg, 80 Cuiyingmen, Lanzhou 730030, Gansu, Peoples R China.
刊名	AMERICAN JOURNAL OF SURGERY
	2009-02
卷号	197 期号:2 页码:246-251
关键词	Gastric neoplasm D1, D2, D3 Meta-analysis Randomized controlled trials
ISSN号	0002-9610
DOI	10.1016/j.amjsurg.2008.05.001
文献子类	Review
英文摘要	BACKGROUND: Several studies in the literature have investigated the possible role of the extent of lymphadenectomy in gastric cancer treatment failure. The current study attempted to determine the effectiveness and safety of lymphadenectomy with gastrectomy for the treatment of gastric cancer. METHODS: Randomized controlled trials (RCTs) were identified by means of MEDLINE, EMBASE, Cochrane Controlled Trials Register databases, and Chinese Biomedical Database, as well as by selecting references from relevant articles. RESULTS: Overall, 14 RCTs (3,432 patients) were included in the meta-analysis. Of the D1 and D2 surgery groups, the operative mortality and postoperative morbidity were higher in the D2 group than in the D1 group, but the 3- and 5-year survival rates were not statistically different. Also the operative time was shorter in D1 compared to D2. In the D2 versus the D3 surgical group, the operative mortality, percentage of postoperative complications, operative time, and hospital stay were not significantly different. CONCLUSIONS: The results suggest that D2 and D3 surgery may not offer specific advantages for gastric cancer and instead may lead to disadvantages for patient outcomes. (C) 2009 Elsevier Inc. All rights reserved.
学科主题	Surgery
出版地	BRIDGEWATER
语种	英语
WOS记录号	WOS:000263454000021
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125995]
专题	第二临床医学院_期刊论文
通讯作者	Zhang, YC (reprint author), Lanzhou Univ, Hosp 2, Dept Gen Surg, 80 Cuiyingmen, Lanzhou 730030, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Yang, SH,Zhang, YC,Yang, KH,et al. An evidence-based medicine review of lymphadenectomy extent for gastric cancer[J]. AMERICAN JOURNAL OF SURGERY,2009,197(2):246-251.
APA	Yang, SH.,Zhang, YC.,Yang, KH.,Li, YP.,He, XD.,...&Zhang, YC .(2009).An evidence-based medicine review of lymphadenectomy extent for gastric cancer.AMERICAN JOURNAL OF SURGERY,197(2),246-251.
MLA	Yang, SH,et al."An evidence-based medicine review of lymphadenectomy extent for gastric cancer".AMERICAN JOURNAL OF SURGERY 197.2(2009):246-251.