Serum matrix metalloproteinase 9 as a marker for the assessment of severe acute pancreatitis

doi:10.1620/tjem.208.261

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	Serum matrix metalloproteinase 9 as a marker for the assessment of severe acute pancreatitis
	Chen, P; Yuan, YZ; Wang, SW; Zhan, LH; Xu, JY; Yuan, YZ (reprint author), Shanghai Med Univ 2, Dept Gastroenterol, Affiliated Ruijin Hosp, Shanghai 200025, Peoples R China.
刊名	TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
	2006-03
卷号	208 期号:3 页码:261-266
关键词	matrix metalloproteinase-9 tumor necorsis factor alpha C-reactive protein acute physiology and chronic health evaluation II score acute pancreatitis
ISSN号	0040-8727
DOI	10.1620/tjem.208.261
文献子类	Article
英文摘要	Previous studies have shown that matrix metalloproteinase 9 (MMP-9) degrades basement membrane components in inflammation, but the change of serum MMP-9 level in the progression of acute pancreatitis remains unclear. The aim of Our study was to assess the value of MMP-9 as a prognostic marker in acute pancreatitis. The prospective study included 10 patients with severe acute pancreatitis (SAP) and 10 patients with mild acute pancreatitis. The study also enrolled 10 healthy individuals as control. The serum MMP-9 level, serum C-reactive protein (CRP) level, serum tumor necrosis factor alpha (TNF-alpha) level and acute physiology and chronic health evaluation (APACHE) II score were measured at 1 hr and 48 hrs after admission. APACHEII scores and serum MMP-9, TNF-alpha and CRP levels were significantly increased in patients with SAP compared to those with mild acute pancreatitis and control subjects at I hr after admission (p < 0.01). When the states of illness were improved, the levels of the above-mentioned markers were decreased in patients with SAP at 48 hrs after admission (1 hr vs 48 hrs. p < 0.01 or p < 0.05). Furthermore, significant positive correlation was found between serum MMP-9 level and serum TNF-alpha level, serum CRP level or APACHEII score in patients at I hr after admission (MMP-9/TNF-alpha, r = 0.956; MMP-9/CRP, r = 0.935; MMP-9/APACHE II score, r = 0.957; p < 0.01). These results suggest that MMP-9 is involved in the deterioration of SAP and serum MMP-9 level is a valuable assessment marker for the severity of SAP.
学科主题	General & Internal Medicine ; Research & Experimental Medicine
出版地	SENDAI
语种	英语
WOS记录号	WOS:000235535800010
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125958]
专题	第二临床医学院_期刊论文
通讯作者	Yuan, YZ (reprint author), Shanghai Med Univ 2, Dept Gastroenterol, Affiliated Ruijin Hosp, Shanghai 200025, Peoples R China.
推荐引用方式 GB/T 7714	Chen, P,Yuan, YZ,Wang, SW,et al. Serum matrix metalloproteinase 9 as a marker for the assessment of severe acute pancreatitis[J]. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,2006,208(3):261-266.
APA	Chen, P,Yuan, YZ,Wang, SW,Zhan, LH,Xu, JY,&Yuan, YZ .(2006).Serum matrix metalloproteinase 9 as a marker for the assessment of severe acute pancreatitis.TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,208(3),261-266.
MLA	Chen, P,et al."Serum matrix metalloproteinase 9 as a marker for the assessment of severe acute pancreatitis".TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 208.3(2006):261-266.