Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK O crossMark and EMT related signals in hepatocellular carcinoma cells

doi:10.1016/j.bmc1.2016.12.073

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	Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK O crossMark and EMT related signals in hepatocellular carcinoma cells
	Bai, ZT; Wu, ZR; Xi, LL; Li, X; Chen, P; Wang, FQ; Meng, WB; Zhou, WC; Wu, XA; Yao, XJ
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2017-02-15
卷号	27 期号:4 页码:989-993
关键词	N-trans-feruloyloctopamine (FO) AKT MAPK E-cadherin Epithelial to mesenchymal transition (EMT) Hepatocellular carcinoma
ISSN号	0960-894X
DOI	10.1016/j.bmc1.2016.12.073
文献子类	Article
英文摘要	N-trans-feruloyloctopamine (FO) isolated from Garlic skin was identified as the primary antioxidant constituents, however, the effect of which on HCC invasion is still unclear. Herein, the FO was synthesized and its antitumor activities were evaluated in HCC cell lines. Cellular functional analyses have revealed that the reformed FO owns strong abilities of inhibiting cell proliferation and invasion in HCC cells. Molecular data have further showed that FO could significantly decrease the phosphorylation levels of Akt and p38 MAPK. In addition, the expression of Slug was inhibited and the level of E-cadherin increased. Molecular docking analysis indicates that the H-bond and hydrophobic interactions were critical for FO and E-cadherin binding, but FO did not seem to act directly on phosphorylated Akt and p38 MAPK. We have thus concluded that reformed FO inhibits cell invasion might be directly through EMT related signals (E-cadherin) and indirectly through PI3K/Akt, p38 MAPK signaling pathways. FO might be a promising drug in HCC treatment and prognosis. (C) 2017 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy ; Chemistry
出版地	OXFORD
资助项目	国家自然科学基金项目 ; 甘肃省杰出青年基金计划 ; 甘肃省自然科学基金计划 ; 甘肃省卫生厅资助项目 ; 兰州市科技局资助项目
项目编号	Gansu Province Science Foundation for Distinguished Young Scholars [1606RJDA317] ; Health Industry Research Project of Gansu Province [GWGL2014-45] ; Science and Technology Program of Lanzhou City [2015-3-93] ; National Natural Science Fund of China [31270543, 31570509] ; Natural Science Foundation of Gansu Province [1208RJZA219, 1606RJZA159, 1606RJZA087]
语种	英语
WOS记录号	WOS:000395967700053
资助机构	NSFC ; GSSTD ; GSPHD ; LZSTB
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188636]
专题	第一临床医学院_期刊论文
通讯作者	Li, X (reprint author), Lanzhou Univ, Dept Gen Surg 2, Clin Med Coll 1, Key Lab Biotherapy & Regenerat Med,Hosp 1, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Bai, ZT,Wu, ZR,Xi, LL,et al. Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK O crossMark and EMT related signals in hepatocellular carcinoma cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(4):989-993.
APA	Bai, ZT.,Wu, ZR.,Xi, LL.,Li, X.,Chen, P.,...&Li, X .(2017).Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK O crossMark and EMT related signals in hepatocellular carcinoma cells.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,27(4),989-993.
MLA	Bai, ZT,et al."Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK O crossMark and EMT related signals in hepatocellular carcinoma cells".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27.4(2017):989-993.