Network meta-analysis of Chinese herb injections combined with FOLFOX chemotherapy in the treatment of advanced colorectal cancer

doi:10.1111/jcpt.12410

CORC > 兰州大学 > 兰州大学 > 第一临床医学院 > 期刊论文

	Network meta-analysis of Chinese herb injections combined with FOLFOX chemotherapy in the treatment of advanced colorectal cancer
	Ge, L; Wang, YF; Tian, JH; Mao, L; Zhang, J; Zhang, JH; Shen, XP; Yang, KH; Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, 199 Dong Gang West Rd, Lanzhou, Gansu, Peoples R China.; Yang, KH (reprint author), Key Lab Evidence Based Med & Knowledge Translat G, 199 Dong Gang West Rd, Lanzhou, Gansu, Peoples R China.
刊名	JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
	2016-08
卷号	41 期号:4 页码:383-391
关键词	Chinese herb injections colorectal cancer FOLFOX network meta-analysis
ISSN号	0269-4727
DOI	10.1111/jcpt.12410
文献子类	Review
英文摘要	What is known and ObjectiveResearch has indicated that some Chinese herb injections (CHIs) might be beneficial in combination with chemotherapy, including remedies that might be used as effective chemosensitizers and radiosensitizers, or as palliative therapy. Here, we carried out a network meta-analysis to assess the clinical efficacy and safety of CHIs combined with oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) for advanced colorectal cancer (CRC). MethodsPubMed, EMBASE.com, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literature Database (CBM), Wanfang Database and Chinese Journal Full-text Database were searched from inception to 31 December 2014, to identify relevant randomized controlled trails (RCTs). The risk of bias in included RCTs was evaluated according to the Cochrane Handbook version 5.1.0. Standard pairwise meta-analysis and Bayesian network meta-analysis were performed to compare the efficacy and safety of different CHIs combined with FOLFOX. Data were analysed using STATA 12.0 and WinBUGS1.4 software. Results and discussionWe identified 63 eligible studies (with 4837 patients in total), involving 9 CHIs. Pairwise meta-analysis showed that compared with FOLFOX alone, combinations with Aidi injection and compound matrine injection could significantly improve the overall response rate and quality of life and reduce the incidence of nausea and vomiting (III-IV), diarrhoea (III-IV), thrombocytopenia (III-IV), leukopenia (III-IV) and peripheral neurotoxicity (III-IV). According to results of indirect comparison, there were no statistically significant differences for most of comparison groups. Aidi+FOLFOX, shenqifuzheng+FOLFOX and compound matrine+FOLFOX had the greatest probability of being the best treatment in clinical efficacy and safety, considering the small sample size. What is new and ConclusionsMost of the included studies were of low quality, and there was a scarcity of eligible trials and numbers of participants. Based on currently limited evidence, aidi, shenqifuzheng and compound matrine were superior to other CHIs in patients receiving FOLFOX chemotherapy for advanced CRC. More studies are required to confirm the efficacy of CHIs in combination with FOLFOX for advanced CRC.
学科主题	Pharmacology & Pharmacy
出版地	HOBOKEN
语种	英语
WOS记录号	WOS:000379683600002
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178666]
专题	第一临床医学院_期刊论文
通讯作者	Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, 199 Dong Gang West Rd, Lanzhou, Gansu, Peoples R China.; Yang, KH (reprint author), Key Lab Evidence Based Med & Knowledge Translat G, 199 Dong Gang West Rd, Lanzhou, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Ge, L,Wang, YF,Tian, JH,et al. Network meta-analysis of Chinese herb injections combined with FOLFOX chemotherapy in the treatment of advanced colorectal cancer[J]. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS,2016,41(4):383-391.
APA	Ge, L.,Wang, YF.,Tian, JH.,Mao, L.,Zhang, J.,...&Yang, KH .(2016).Network meta-analysis of Chinese herb injections combined with FOLFOX chemotherapy in the treatment of advanced colorectal cancer.JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS,41(4),383-391.
MLA	Ge, L,et al."Network meta-analysis of Chinese herb injections combined with FOLFOX chemotherapy in the treatment of advanced colorectal cancer".JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS 41.4(2016):383-391.