Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients

doi:10.4103/0366-6999.178959

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	Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients
	Yu, H; Xie, LF; Chen, K; Yang, GY; Xing, XY; Zhao, JJ; Hong, TP; Shan, ZY; Li, HM; Chen, B
刊名	CHINESE MEDICAL JOURNAL
	2016-04-05
卷号	129 期号:7 页码:778-784
关键词	Obesity Risk Factor Type 2 Diabetes Mellitus Young
ISSN号	0366-6999
DOI	10.4103/0366-6999.178959
文献子类	Article
英文摘要	Background: Type 2 diabetes mellitus (T2DM) has traditionally been considered to affect mainly the elderly; however, the age at diagnosis has gradually reduced in recent years. Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. The aim of this study was to describe the initiating characteristics of early-onset T2DM in Chinese patients and evaluate the risk factors for diabetes mellitus. Methods: This cross-sectional controlled study was performed using a questionnaire survey method in outpatients of multiple centers in China. A total of 1545 patients with T2DM with an age at onset of <40 years were included, and the control group consisted of subjects aged <40 years with normal blood glucose level. Results: In patients with young-onset T2DM, the mean age and initial hemoglobin 1Ac at diagnosis were 32.96 +/- 5.40 years and 9.59 +/- 2.71%, respectively. Most of the patients were obese, followed irregular diet pattern and sedentary lifestyle, had life or work pressure, and had a family history of diabetes mellitus. Compared with subjects with normal blood glucose level, logistic regression analysis showed that waist-to-hip ratio (odds ratio [OR] 446.99, 95% confidence interval [CI] 42.37-4714.87), family history of diabetes mellitus (OR 23.46, CI 14.47-38.03), dyslipidemia (OR 2.65, CI 1.54-4.56), diastolic blood pressure (OR 1.02, CI 1.00-1.04), and body mass index (OR 0.95, CI 0.92-0.99) are independent factors for early-onset T2DM. Conclusions: We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. It is, therefore, necessary to apply early lifestyle intervention in young people with risk of diabetes mellitus.
学科主题	General & Internal Medicine
出版地	MUMBAI
资助项目	国家科技重大专项
项目编号	National Science and Technology Major Project [2011ZX09307-001-08]
语种	英语
CSCD记录号	CSCD:5674625
WOS记录号	WOS:000373387000004
资助机构	MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178639]
专题	第一临床医学院_期刊论文
通讯作者	Mu, YM (reprint author), Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, 28 Fuxing Rd, Beijing 100853, Peoples R China.
推荐引用方式 GB/T 7714	Yu, H,Xie, LF,Chen, K,et al. Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients[J]. CHINESE MEDICAL JOURNAL,2016,129(7):778-784.
APA	Yu, H.,Xie, LF.,Chen, K.,Yang, GY.,Xing, XY.,...&Mu, YM .(2016).Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients.CHINESE MEDICAL JOURNAL,129(7),778-784.
MLA	Yu, H,et al."Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients".CHINESE MEDICAL JOURNAL 129.7(2016):778-784.