A Study of the Relaxed Mechanisms Induced by Novokinin in the Isolated Porcine Coronary Artery Ring Segments

doi:10.2174/0929866522666150921113224

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	A Study of the Relaxed Mechanisms Induced by Novokinin in the Isolated Porcine Coronary Artery Ring Segments
	Xu, PH; Wang, T; Li, L; BoZhang; Wu, CX; Yao, YL; Zhang, Z; Zhang, Z (reprint author), Lanzhou Univ, Affiliated Hosp 1, Key Lab Cardiovasc Dis, Dept Cardiovasc Div, 1 West Dong Gang Rd, Lanzhou 730000, Gansu, Peoples R China.
刊名	PROTEIN AND PEPTIDE LETTERS
	2015
卷号	22 期号:12 页码:1083-1088
关键词	Novokinin Porcine coronary artery NO Cyclic guanosine monophosphate prostaglandin Adrenergic beta-receptor
ISSN号	0929-8665
DOI	10.2174/0929866522666150921113224
文献子类	Article
英文摘要	Novokinin is a vasorelaxing peptide designed according to the structure of ovokinin(2-7) that is released from ovalbumin by chymotryptic digestion. It has attracted much attention due to its variety of pharmacological and biological characteristics. The purpose of this research was to judge the effect and the mechanism of novokinin on porcine coronary arteries. The isometrical tension of coronary arterial rings getted from porcine hearts was measured and its reaction to novokinin (10(-12)-10(-5) mol/L) was observed. It was found that novokinin inhibited the vasocontractivity to KCl and CaCl2 and evidently decreased the isomeric tensile force of both quiescent and prostaglandin F2 alpha (PGF2 alpha) precontracted porcine coronary arterial ring segments. This relaxing effect of novokinin on porcine coronary arteries was apparently cutted down by getting rid of endothelium, and by the addition of methylene blue, N-nitro-L-arginine (L-NNA) or indomethacin, but not by propranolol. Novokini also inhibited the KCl- and CaCl2-induced vasocontraction. The experimental results show that relaxed effect of novokinin on porcine coronary arteries might relate to the function of nitric oxide (NO), cyclic guanosine monophosphate (cGMP) and the synthesis of prostaglandin, but not involve adrenergic beta-receptor.
学科主题	Biochemistry & Molecular Biology
出版地	SHARJAH
语种	英语
WOS记录号	WOS:000365041200005
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178519]
专题	第一临床医学院_期刊论文
通讯作者	Zhang, Z (reprint author), Lanzhou Univ, Affiliated Hosp 1, Key Lab Cardiovasc Dis, Dept Cardiovasc Div, 1 West Dong Gang Rd, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Xu, PH,Wang, T,Li, L,et al. A Study of the Relaxed Mechanisms Induced by Novokinin in the Isolated Porcine Coronary Artery Ring Segments[J]. PROTEIN AND PEPTIDE LETTERS,2015,22(12):1083-1088.
APA	Xu, PH.,Wang, T.,Li, L.,BoZhang.,Wu, CX.,...&Zhang, Z .(2015).A Study of the Relaxed Mechanisms Induced by Novokinin in the Isolated Porcine Coronary Artery Ring Segments.PROTEIN AND PEPTIDE LETTERS,22(12),1083-1088.
MLA	Xu, PH,et al."A Study of the Relaxed Mechanisms Induced by Novokinin in the Isolated Porcine Coronary Artery Ring Segments".PROTEIN AND PEPTIDE LETTERS 22.12(2015):1083-1088.