Elevated plasma sphingomyelin (d18:1/22:0) is closely related to hepatic steatosis in patients with chronic hepatitis C virus infection

doi:10.1007/s10096-014-2123-x

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	Elevated plasma sphingomyelin (d18:1/22:0) is closely related to hepatic steatosis in patients with chronic hepatitis C virus infection
	Li, JF; Qu, F; Zheng, SJ; Wu, HL; Liu, M; Liu, S; Ren, Y; Ren, F; Chen, Y; Duan, ZP
刊名	EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
	2014-10
卷号	33 期号:10 页码:1725-1732
ISSN号	0934-9723
DOI	10.1007/s10096-014-2123-x
文献子类	Article
英文摘要	Hepatic steatosis affects disease progression in patients with chronic hepatitis C virus (HCV) infection. We investigated the plasma sphingolipid profile in patients with chronic hepatitis C (CHC) and whether there was an association between HCV-related steatosis and plasma sphingolipids. We used high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to analyze plasma sphingolipids in 120 interferon-naive, non-diabetic, and non-obese CHC patients. Hepatic steatosis was defined as >= 5 % hepatocytes with fat based on histopathological analysis. Blood biochemical indicators and HCV load and genotype were also determined. Thirty-six (30.0 %) of 120 patients presented with hepatic steatosis Grades 1-3. Forty-four plasma sphingolipids were detected. Plasma sphingomyelin (SM) (d18:1/22:0) and ceramide (Cer) (d18:1/24:0)-1-P correlated with steatosis grade (r=0.22, p=0.015; r=-0.23, p=0.012, respectively). SM (d18:1/22:0) [ odds ratio (OR)=1.12] and Cer (d18:1/24:0)-1-P (OR=0.88) were independent factors for the presence of hepatic steatosis in CHC patients. The area under the curve (AUC) of SM (d18:1/22:0) and Cer (d18:1/24:0)-1-P was 0.637 and 0.638, respectively, to identify the presence of steatosis. Further analysis for genotype 2 CHC showed that only SM (d18: 1/22: 0) was independently linked to steatosis (OR=1.21). The AUC of SM (d18:1/22:0) to identify hepatic steatosis in genotype 2 CHC was 0.726. Its sensitivity and negative predictive value reached 0.813 and 0.886, respectively. This study suggested that altered plasma SM (d18:1/22:0) was closely related to hepatic steatosis in chronic HCV infection, especially with genotype 2. Experimental studies are needed to determine further the underlying mechanisms responsible for these associations.
学科主题	Infectious Diseases ; Microbiology
出版地	NEW YORK
资助项目	国家科技重大专项
项目编号	National Science and Technology Key Project of China [2012ZX10002004-006, 2012ZX10004904-003-001, 2013ZX10002002-006] ; Ministry of Science and Technology of China [2012ZX09301002-006] ; High Technical Personnel Training Item in Beijing Health System [2011-3-083] ; Beijing Municipal Science & Technology Commission [Z131107002213019] ; Special Scientific Research Fund for Beijing Health Development [2011-2018-04] ; YouAn Scientific Research Fund for Liver Disease and HIV/AIDS [BJYAH-2011-045]
语种	英语
WOS记录号	WOS:000343139000007
资助机构	MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125891]
专题	第一临床医学院_期刊论文
通讯作者	Duan, ZP (reprint author), Capital Med Univ, Beijing YouAn Hosp, Artificial Liver Ctr, 8 Xitoutiao,Youwai St, Beijing 100069, Peoples R China.
推荐引用方式 GB/T 7714	Li, JF,Qu, F,Zheng, SJ,et al. Elevated plasma sphingomyelin (d18:1/22:0) is closely related to hepatic steatosis in patients with chronic hepatitis C virus infection[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,2014,33(10):1725-1732.
APA	Li, JF.,Qu, F.,Zheng, SJ.,Wu, HL.,Liu, M.,...&Duan, ZP .(2014).Elevated plasma sphingomyelin (d18:1/22:0) is closely related to hepatic steatosis in patients with chronic hepatitis C virus infection.EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,33(10),1725-1732.
MLA	Li, JF,et al."Elevated plasma sphingomyelin (d18:1/22:0) is closely related to hepatic steatosis in patients with chronic hepatitis C virus infection".EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 33.10(2014):1725-1732.